Rapid Detection for Pollutants and Bacteria Based on Quartz Crystal Microbalance Biosensor (pp. 171-192)
Authors: (Zhixian Gao, Nan Liu, Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Health and Environmental Medicine, Tianjin, China)
Abstract: QCM technique is a powerful tool with advantages of high sensitivity, real time
measurement, free-labeling, etc. has been widely used in food safety, environment
monitoring and veterinary diagnosis. QCM has been used as an active mode sensor for
the direct detection of molecular interactions by oscillating the sensor surface and
monitoring the acoustic emission produced by bond rupture.
Here, QCM biosensors for the rapid detection for pollutants and bacteria are
reviewed. As molecular recognitions are mostly occurring on the surface of the quartz
crystal, the sensitive recognition elements such as MIP flim, aptamer coated film,
micro/nanomaterials coated on QCM chip and carbon nanotubes coated electrode are
narrated. It can detect the trace mass change in the nanogram range onto the electrode
surface of quartz crystal in air or liquid. The most popular QCM biosensors such as QCM
based on immunological method, QCM based on molecularly imprinted technology DNA
QCM biosensor and QCM with dissipation (QCM-D) biosensor are discussed in details.
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