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Research Progress in Alzheimer's Disease and Dementia. Volume 1
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Editors: Miao-Kun Sun (Blanchette Rockefeller Neurosciences Institute)
Book Description:
Alzheimerís disease (AD) is the most common type of neurodegenerative disorder in the aging population, with dementia as a common consequence. AD is defined pathologically by the appearance of extracellular senile plaques and intracellular neurofibrillary tangles, as described by Alois Alzheimer about a century ago. The causes for AD include genetic predisposition in a small population, aging and environmental stresses in majority cases. The underlying pathogenic cascades, increases in expression of amyloid precursor protein and accumulation of A and reactive oxidant activity and inflammation, have the features of both adaptive, at least initially, and harmful when becoming excessive.
Dementia, on the other hand, is a clinical diagnosis and is defined as globally, persistently impaired cognitive skills including memory. Alzheimer dementia refers to clinical dementia in patients who also have Alzheimer neuropathology. Alzheimer dementia is what brings the patients to seek medical treatments. An extraordinary inability to form new memory, especially of those episodic type, and executive dysfunction are among the earliest symptoms in AD patients. In end-stage AD, cognitive degeneration extends far beyond memory loss. The underlying causes include decreases in impaired brain metabolism, which results in impaired synaptic functions and capacities, thus impaired information processing, and eventually leads to neuronal injury and death.
This new book presents leading-edge research in this dynamic field.

Table of Contents:
Preface:

Abbreviations

Chapter 1.-Neuroimaging in Alzheimerís Disease and Mild Cognitive Impairment; pp. 1-24
(Effie M. Mitsis and Christopher H. van Dyck)

Chapter 2.-Executive Dysfunction in Alzheimerís Disease; pp. 25-38
(Maureen K. OíConnor and Patricia A. Boyle)

Chapter 3.-Alzheimerís Disease Therapies: Updates on Genetic and Pharmacological Manipulations of -Secretase; pp. 39-59
(Masuo Ohno and John F. Disterhoft)

Chapter 4.-Neuronal Deregulation of Tau Phosphorylation: Implications for Mechanisms and Treatment of Alzheimer's Disease; pp. 61-78
(Akihiko Takashima)

Chapter 5.-Immunotherapeutic approach in Alzheimer's disease;
pp. 79-95
(Dan Frenkel and Howard L. Weiner)

Chapter 6.-Immunotherapy for Alzheimerís Disease and Dementia;
pp. 97-109
(Anthony R. White)

Chapter 7.-A-degrading Enzyme, Eprilysin; pp. 111-145
(Nobuhisa Iwata, Makoto Higuchi and Takaomi C. Saido)

Chapter 8.-Memantine as an Antidementic Drug; pp. 147-176
(Miao-Kun Sun)

Chapter 9.-Neurogenesis and Alzheimerís Disease;
pp. 177-190
(David A. Greenberg, Kunlin Jin, Veronica Galvan and Dale E. Bredesen)

Chapter 10.-Glyoxalase I and its Role in Human Disease; pp. 191-204
(JŁrgen GŲtz and Feng Chen)

Chapter 11.-Brain insulin Function and Insulin Signal Transduction in Sporadic Alzheimer Disease; pp. 205-255
(Siegfried Hoyer and Lutz FrŲlich)

Chapter 12.-Apolipoprotein E and Cerebral Amyloid Angiopathy in Alzheimerís Disease; pp. 257-284
(Katy Chalmers and Seth Love)

Chapter 13.-Limbic Metabolic Changes and Alzheimerís Disease;
pp. 285-299
(Peter J Nestor and John R Hodges)

Chapter 14.-Oxidative Damage is the Earliest Change of Alzheimer Disease: Therapeutic Opportunities; pp. 301-317
(Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith and George Perry)

Chapter 15.-Chronic Antioxidant Treatments and Memory in a Transgenic Mouse Model of Alzheimerís Disease; pp. 319-341
(Robert W. Stackman Jr. and Joseph F. Quinn)

Chapter 16.-Drosophila as a Model for Studying Disease Mechanisms of Alzheimerís and Related Dementia; pp. 343-359
(Bingwei Lu)

Chapter 17.-Androgens, ApoE, and Alzheimerís Disease; pp. 361-387
(Jacob Raber)

Chapter 18.-Pivotal Roles of Cholesterol and Gangliosides in Aggregation of Amyloid -protein; pp. 389-401
(Katsuhiko Yanagisawa)

Chapter 19.-Imaging Cerebral Atrophy in Alzheimerís Disease;
pp. 403-435
(Jo Barnes, H. Archer and Nick C. Fox)

Contributors

Index

   Series:
      Research Progress in Alzheimer's Disease and Dementia
   Binding: Hardcover
   Pub. Date: 2007
   Pages: 7x10
   ISBN: 978-1-59454-949-6
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Research Progress in Alzheimer's Disease and Dementia. Volume 1