Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Chemistry including Chemical Engineering » Advances in Chemistry Research. Volume 18 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
What Your Eyes Tell Your Brain about Art: Insights from Neuroaesthetics and Scanpath Eye Movements
$95.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Recent Advances in Asymmetric Diels-Alder Reactions (pp. 179-220)
Tell A Friend
 
Tell someone you know about this product.
Recent Advances in Asymmetric Diels-Alder Reactions (pp. 179-220) $0.00
Authors:  (Jonathan P. Miller, Oxford International College of Chengdu, Chenghua District, Chengdu, P. R. China)
Abstract:
Since the discovery of the Diels-Alder reaction over eighty years ago, it has
transformed a synthetic chemist's arsenal of tools to construct intermolecular and
intramolecular cyclic rings. More importantly, these pericyclic reactions are being
utilised for their stereocontrol to provide chiral building blocks and target compounds,
including those with heteroatoms, with high enantioselectivities. Its versatility can
provide up to four contiguous asymmetric centres with good yields, as many as three
carbocyclic rings in the intramolecular and transannular variations, endo-selectivity and
facile manipulation of the cycloadducts. Many chiral auxiliaries are being used either on
the diene or dienophile, such as D-glucose. Historically, there was a preference for chiral
transition-metal complexes/Lewis acids or enzymes and more recently organocatalysts
(including secondary amines) are gaining prominence with achiral substrates as well as
new transition metal catalysts for even better stereocontrol. Hetero-Diels-Alder reactions
(e.g. the aza-Diels-Alder) are also widely reported in asymmetric synthesis and special
attention will be paid to these, including those with inverse-electron-demand.
This review sources the more recent advances presented in the chemical literature
with a view to constructing biologically interesting and diverse molecules of interest to
the pharmaceutical and related industries. Some classics (in part) are also described. The
review focuses on the mechanism of the Diels-Alder and related reactions where
required, endo-transition states, regioselectivities and HOMO-LUMO orbital interactions.
This builds upon earlier reviews and book chapters and pulls together important
developments in the areas highlighted above concisely into a single chapter. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Medical Cannabis: Clinical Practice
02.Hemorrhagic Shock: Recognition, Pathophysiology and Management
03.Patellofemoral Pain: An Evidence-Based Clinical Guide
04.Neanderthals in Plato’s Cave: A Relativistic Approach to Cultural Evolution
05.My Patients Were Mummies
06.‘L’Atelier Moderne’: An Exploration of the Collaborative Process Between Performer and Composer in Vocal Music Theatre of the 21st Century (CD Included)
07.The Voice at the End of the Telephone Line: The Psychology of Tele Carers
08.Caught up in the Spirit! Teaching for Womanist Liberation
09.The Transgender Handbook: A Guide for Transgender People, Their Families and Professionals
10.Mastering Science with Metacognitive and Self-Regulatory Strategies: A Teacher-Researcher Dialogue of Practical Applications for Adolescent Students
11.Political Migrations in Poland in the Period of World War II
12.Sociolinguistic Parallels Across Europe: Focus on Lowland Scotland and the Eastern Slavic Countries

Nova Science Publishers
© Copyright 2004 - 2017

Recent Advances in Asymmetric Diels-Alder Reactions (pp. 179-220)