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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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Gene Silencing: New Research
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Editors: Grace W. Redberry
Book Description:
Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the "switching off" of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. Interestingly, mechanisms of gene silencing also protect the organism's genome from transposons, viruses. This new book presents the latest research in this important field.

Table of Contents:

Chapter I. High Frequent Gene Silencing of Hemetopoietic Cell Specific Protein Tyrosinephosphatase SHP1 in Hemetopoietic Cell Malignancies; pp. 1-32
(Takashi Oka, et al., Okayama University Graduate School of Medicine and Dentistry, Japan)

Chapter II.Age Management Treatments Which Target Silenced Genes;
pp. 33-80
(Stanislaw R. Burzynski, Burzynski Clinic)

Chapter III. Gene Silencing in Tumors: The Role of the Ras Association Domain Family 1 Gene in Carcinogenesis; pp. 81-119
(Reinhard Dammann, Martin Luther University, Germany)

Chapter IV. Human DNA cis-Elements Protecting the VHL Promoter and CpG Island from Methylation are Functional in the Mouse; pp. 121-141
(Igor Kuzmin, et al, Laboratory of Immunobiology, Maryland)

Chapter V. Intron-Mediated Gene Silencing; pp. 143-163
(Shi-Lung Lin and Shao-Yao Ying, Keck School of Medicine, University of Southern California)

Chapter VI. DNA Methylation and Epigenetic Gene Silencing in Breast Cancer; pp. 165-191
(Qifeng Yang, et al., Department of Genetics, Rutgers University, NJ).


   Binding: Hardcover
   Pub. Date: 2006
   ISBN: 978-1-59454-832-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Gene Silencing: New Research