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Are Chronic Degenerative Diseases Part of the Ageing Process? Insights from Comparative Biology
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Authors: Michael A. Singer (Queen's University, Kingston, Ontario, Canada) 
Book Description:
Most of the DNA in the human genome does not encode proteins but is involved in regulatory functions. In addition, the human genome is characterized by an extensive array of structural DNA variants arising from de novo mutations plus accumulated structural variants transmitted through an individual’s lineage. The result is that each person has a unique genome which is expressed as that person’s unique phenotype. Ageing can be understood on both the species and individual level. Each species has a programmed ageing and mortality pattern, but within those broad species-specific boundaries there is considerable individual variation. At the individual level, ageing reflects the integrated effects of that individual’s unique mix of DNA structural variants, unique experience-specific epigenetic marks and imperfectly repaired genomic and cellular damage. This book examines human “chronic degenerative” diseases which are not diseases, but rather variations of the ageing process across individuals. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp. i-xi

Introduction

Chapter 1: Background pp. 1-28

Chapter 2: Atherosclerotic Vascular Disease pp. 29-50

Chapter 3: Hypertension pp. 51-86

Chapter 4: Diabetes Mellitus (Type 2)pp. 87-124

Chapter 5: Dementia pp. 125-166

Chapter 6: Conclusions pp. 167-200

References

Index pp. 201-217

   Series:
      Aging Issues, Health and Financial Alternatives
   Binding: Hardcover
   Pub. Date: 2013- March
   Pages: 228, 7x10 - (NBC-C)
   ISBN: 978-1-62618-013-0
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Are Chronic Degenerative Diseases Part of the Ageing Process? Insights from Comparative Biology