Functional Neurology and Immunology: V. Neuroautoimmunity and its Origins, Mechanisms, Assessments (pp. 615-630)
Authors: Aristo Vojdani and Jama Lambert
Abstract: Neurologists and immunologists have been debating the mechanisms of neuro-degenerative disorders since they were first described. These multi-faceted diseases pose clinical challenges for the practitioner attempting to predict, diagnose, manage or treat afflicted patients. Understanding the integrated neuroimmune response mechanisms leading to neuroautoimmunity and utilizing the measurements of predictive antibodies can help. Here we review some of the stressors (heavy metals, chemicals, viruses, bacteria, emotional stress) that trigger systemic inflammation and map the cascade of mechanisms (transmigration, molecular mimicry, cross-reactivity, bystander activation) that lead to neurodegeneration. We conclude that a thorough evaluation of each patientís stressors, mechanisms, neuroimmune function and target tissue antigens should be assessed in order to properly manage neuroautoimmunity and neuro-degenerative diseases.