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Vimentin Concepts and Molecular Mechanisms
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Editors: Ramon Andrade de Mello (Oncology Portuguese Institute of Porto Francisco Gentil, Department of Medical Oncology, Porto, Portugal)
Book Description:
Intermediate filaments (IFs) are among the main cytoskeleton components in most animal cells, being intermediate in diameter between microtubules and actin filaments. Vimentin is one of the large intermediate filaments (IFs) of eukaryotic cell’s cytoskeleton, being the major protein in mesenchymal cells and it is frequently used as a developmental marker of cells and tissues. It may be overexpressed in several cancers, such as lung, breast, head and neck cancer, and sarcomas. Furthermore, it plays a main role in rheumatoid arthritis and Crohn's disease. Thus, this book will address main topics concerning promising therapeutic targets for intestinal fibrosis, vimentin's potential role in epithelial mesenchymal transition (EMT), the role of vimentin in rheumatoid arthritis, vimentin mechanisms and endothelial migration, and EMT and lung neoplasms. Also discussed are insights into the proteomics’ field. Many reputed experts worldwide contributed to improvement of this book and it will give readers the state of art regarding vimentin and novel approaches. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp. i-xi

Chapter 1: Introduction to Vimentin and Novel Approaches
(Daniel Humberto Pozza and Ramon Andrade de Mello, Faculty of Medicine of the University of Porto, Porto, Portugal and others) pp. 1-6

Chapter 2: Vimentin during Development: Expression, Regulation and Functions
(Zhenlin Li, Philippe Duprey, Araksya Izmyrian, Ara Parlakian, Jocelyne Blanc, Zhigang Xue and Denise Paulin, UPMC University, Paris, France and others)pp. 7-26

Chapter 3: Vimentin-Positive, Profibrogenic Mesenchymal Cells in Intestine: Promising Therapeutic Targets for Intestinal Fibrosis
(Kenji Suzuki, Masaki Nagata, Tomoyuki Kawase, Kohya Uematsu, Yutaka Honda, Yusuke Kawauchi, Junji Yokoyama, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Hiroyuki Yoneyama, Kenichi Watanabe, and Hitoshi Asakura, Department of Medicine (III), Niigata University Medical and Dental Hospital, Niigata, Japan and others)pp. 27-36

Chapter 4: Intermediate Filament Vimentin and Potential Role in Epithelial Mesenchymal Transition (EMT)
(Sukhwinder Singh Sohal, Amir Soltani, Steven Weston, Richard Wood-Baker and Haydn Walters, NHMRC National Centre for Research Excellence in Chronic Respiratory Disease, Menzies Research Institute, Australia)pp. 37-62

Chapter 5: The Role of Vimentin in Rheumatoid Arthritis
(Katleen Van Steendam, Marlies De Ceuleneer and Dieter Deforce. Laboratory for Pharmaceutical Biotechnology, University Ghent, Belgium)pp. 63-80

Chapter 6: Vimentin Mechanisms on Endothelial Migration
(Taavi Päll, Tallinn University of Technology, Department of Gene Technology;
Competence Centre for Cancer Research, Tallinn, Estonia)pp. 81-96

Chapter 7: Vimentin Expression in Head and Neck Cancer
(Aluana Maria da Costa Dal Vechio, Department of Stomatology, School of Dentistry, University of São Paulo, Brazil)pp. 97-108

Chapter 8: EMT Status in Lung Neoplasm
(Hidetaka Uramoto and Fumiriro Tanaka, Second Department of Surgery,
University of Occupational and Environmental Health, Kitakyushu, Japan) pp. 109-120

Chapter 9: Vimentin and Proteomics
(Peirong Wang and Nanbert Zhong, Peking University Center of Medical Genetics and Department of Medical Genetics of Peking University Health Science Center, Beijing, China and others) pp. 121-162

Index pp. 163-174

      Protein Biochemistry, Synthesis, Structure and Cellular Functions
      Protein Science and Engineering
   Binding: Hardcover
   Pub. Date: 2013- March
   Pages: 185, 7x10 - (NBC-C)
   ISBN: 978-1-62417-359-2
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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