Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Neurosciences » Astrocytes: Structure, Functions and Role in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
A Comprehensive Investigation on Executive-Employee Pay Gap of Chinese Enterprises: Antecedents and Consequences
$279.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)
Tell A Friend
 
Tell someone you know about this product.
Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144) $100.00
Authors:  (Raul Estevez, Department Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain and others)
Abstract:
In the normal CNS, astrocytes actively regulate normal brain function. The regulation of processes related to brain homeostasis and myelination seems to be its major task. The role of astrocytes in myelin biology is impressively illustrated by mutations in astrocyte-expressed genes in human leukodystrophies (genetic diseases of the white matter).
We review here Megalencephalic leukoencephalopathy with subcortical cysts (MLC), which is a vacuolating myelinopathy.
The genes affected in this disease code for a membrane protein with low homology to ion channels (MLC1) and an adhesion membrane protein of poorly characterized function (GlialCAM), which acts as an escort molecule of MLC1. In addition, GlialCAM functions as an auxiliary subunit of the chloride channel ClC-2, and ClC-2 knockout mice display an MLC-like phenotype.
We provide here an introduction about this disorder and review the last findings. The study of MLC disease provides new exciting insights about the role of astrocytes in the process of myelin homeostasis. 


Available Options:
Version:
Special Focus Titles
01.Essays on the Philosophical Nexus between Religion and Politics. Volume 2
02.Glaciology for Glacial Geologists
03.Tropical Fruits: From Cultivation to Consumption and Health Benefits, Fruits from the Amazon
04.The Copper Garden: New Zealand Novels
05.Informed Parents, Healthy Kids: Information You Need to Know to Find the Right Mental Health Practitioner
06.An Echo of Silence: A Comprehensive Research Study on Early Child Marriage (ECM) in Iran
07.Panic Disorder: Assessment, Management and Research Insights
08.Multiple Sclerosis in Children and Adolescents
09.Parkinsonís Disease: Awareness among Young Adults
10.Cancer and Exercise
11.Psychobiological, Clinical, and Educational Aspects of Giftedness
12.Why 40%-80% of Chronic Pain Patients Are Misdiagnosed and How to Correct That

Nova Science Publishers
© Copyright 2004 - 2018

Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)