Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Neurosciences » Astrocytes: Structure, Functions and Role in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Glyphosate: Chemistry, Uses and Safety Concerns
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)
Tell A Friend
Tell someone you know about this product.
Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144) $100.00
Authors:  (Raul Estevez, Department Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain and others)
In the normal CNS, astrocytes actively regulate normal brain function. The regulation of processes related to brain homeostasis and myelination seems to be its major task. The role of astrocytes in myelin biology is impressively illustrated by mutations in astrocyte-expressed genes in human leukodystrophies (genetic diseases of the white matter).
We review here Megalencephalic leukoencephalopathy with subcortical cysts (MLC), which is a vacuolating myelinopathy.
The genes affected in this disease code for a membrane protein with low homology to ion channels (MLC1) and an adhesion membrane protein of poorly characterized function (GlialCAM), which acts as an escort molecule of MLC1. In addition, GlialCAM functions as an auxiliary subunit of the chloride channel ClC-2, and ClC-2 knockout mice display an MLC-like phenotype.
We provide here an introduction about this disorder and review the last findings. The study of MLC disease provides new exciting insights about the role of astrocytes in the process of myelin homeostasis. 

Available Options:
Special Focus Titles
01.Laryngeal Cancer: Risk Factors, Symptoms and Treatment
02.Breast Surgery: Indications and Techniques
03.Cursed? Biologic and Cultural Aspects of the Menstrual Cycle and Menstruation
04.The Uses of Cocoa and Cupuaçu Byproducts in Industry, Health, and Gastronomy
05.Agriculture, Food, and Food Security: Some Contemporary Global Issues
06.Fungicides: Perspectives, Resistance Management and Risk Assessment
07.Current Developments in Alexithymia - A Cognitive and Affective Deficit
08.Political Concerns and Literary Topoi in French Grand Opera
09.Abdul Aziz Said: The Mualim, The Inspiration
10.Teachers and Teaching: Global Practices, Challenges, and Prospects
11.A Comprehensive Investigation on Executive-Employee Pay Gap of Chinese Enterprises: Antecedents and Consequences
12.American Alligators: Habitats, Behaviors, and Threats

Nova Science Publishers
© Copyright 2004 - 2018

Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)