Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Neurosciences » Astrocytes: Structure, Functions and Role in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
The Process of Enterprise Risk Management
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)
Tell A Friend
Tell someone you know about this product.
Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144) $100.00
Authors:  (Raul Estevez, Department Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain and others)
In the normal CNS, astrocytes actively regulate normal brain function. The regulation of processes related to brain homeostasis and myelination seems to be its major task. The role of astrocytes in myelin biology is impressively illustrated by mutations in astrocyte-expressed genes in human leukodystrophies (genetic diseases of the white matter).
We review here Megalencephalic leukoencephalopathy with subcortical cysts (MLC), which is a vacuolating myelinopathy.
The genes affected in this disease code for a membrane protein with low homology to ion channels (MLC1) and an adhesion membrane protein of poorly characterized function (GlialCAM), which acts as an escort molecule of MLC1. In addition, GlialCAM functions as an auxiliary subunit of the chloride channel ClC-2, and ClC-2 knockout mice display an MLC-like phenotype.
We provide here an introduction about this disorder and review the last findings. The study of MLC disease provides new exciting insights about the role of astrocytes in the process of myelin homeostasis. 

Available Options:
Special Focus Titles
01.Peter Singerís Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

Astrocyte dysfunction in megalencephalic leukoencephalopathy with Subcortical Cysts (pp.125-144)