Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Nutrition » Curcumin: Biosynthesis, Medicinal Uses and Health Benefits Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Development of the Cerebellum: Clinical and Molecular Perspectives
$85.50
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Pharmaceutical Implications of Curcumin in the Development of Drugs for CF Pharmacotherapy: Combined Effects with Genistein (pp. 223-234)
Tell A Friend
 
Tell someone you know about this product.
Pharmaceutical Implications of Curcumin in the Development of Drugs for CF Pharmacotherapy: Combined Effects with Genistein (pp. 223-234) $100.00
Authors:  (Yoshiro Sohma, Ying-chun Yu, Haruna Miki, Yumi Nakamura, Akiko Hanyuda, Hui-Yi Lin, Masato Yasui, Silvia Bompadre, Tzyh-Chang Hwang, Departments of Pharmacology, Keio University School of Medicine, Shinjuku, Tokyo, Japan, and others)
Abstract:
The Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel
plays an essential role in salt and water transport across epithelia and mutations of CFTR
causing its dysfunction result in the genetic disease cystic fibrosis (CF). Various
mutations induce CFTR channel dysfunction and various pharmacological approaches are
currently being explored.
The G551D mutation in CFTR is a common cause of CF, characterized by an
extremely low open probability despite its normal trafficking to the plasma membrane.
Recently we investigated the potentiation effect of curcumin, especially its combined
effect with a flavonoid genistein, on G551D-CFTR activity using the patch-clamp
technique. Curcumin potentiated G551D-CFTR less than genistein at their maximally
effective concentrations. However, curcumin showed an additive effect with genistein
and, more importantly, a significant synergistic effect with genistein in a low
concentration range. This does not only suggest that multiple mechanisms are involved in
action of the CFTR potentiators, but also pose pharmaceutical implications of curcumin in the development of drugs for CF pharmocotherapy. 


Available Options:
Version:
Special Focus Titles
01.Peter Singerís Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

Pharmaceutical Implications of Curcumin in the Development of Drugs for CF Pharmacotherapy: Combined Effects with Genistein (pp. 223-234)