Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Ferritin: Functions, Biosynthesis and Regulation » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Bioactive Compounds: Sources, Properties and Applications
$230.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Ferritin as an Iron Source for Pathogens (pp.1-46)
Tell A Friend
 
Tell someone you know about this product.
Ferritin as an Iron Source for Pathogens (pp.1-46) $0.00
Authors:  (Fernando López-Soto, Carolina Piña-Vázquez, Jesús Serrano-Luna, Carmen Candia-Plata, Mireya de la Garza, Laboratorio de Bioquímica de Proteínas, Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Hermosillo, Sonora, México)
Abstract:
In this chapter we analyze the interaction between the host ferritin and pathogenic microorganisms, since this ferric protein can be used by invaders for their growth and, thus, colonization and invasion of tissues, causing disease. Iron is an essential nutrient for all living beings; however, this metal is toxic and must be captured by proteins, among them ferritin, the great intracellular storage of iron in the body. Pathogens living inside humans also need the vital iron; therefore, the iron availability in body tissues plays a crucial role in the host-pathogen relationship. In general, microorganisms living within a mammal have
evolved several mechanisms to scavenge iron from the host iron-containing proteins; these mechanisms have been considered to be important virulence factors. Pathogens able to destroy cells and tissues can have easy access to ferritin and make use of its iron. Due to the high amount of iron atoms that ferritin is able to capture, this protein is really a remarkable iron source for every intracellular pathogen. In the literature, there are only a few reports about pathogens using ferritin as an iron source, but this is an exciting growing field of research. Each pathogen has developed its own manner to obtain iron from ferritin: for instance, the bacterium Neisseria meningitidis triggers the host ferritin redistribution from cytosol to lysosomes within infected epithelial cells and accelerates the ferritin degradation by lysosomal proteases, thus providing the necessary iron for its own existence. On the other hand, in spite of being ferritin a stable supramolecular complex, Burkholderia cenocepacia secretes serine-proteases that degrade ferritin. Some strains of Escherichia coli and Mycobacterium secrete siderophores, ultra-high affinity iron-binding compounds able to confiscate iron to host ferritin. Another mechanism to get ferritin iron is the reported in Listeria monocytogenes and the mucosal pathogenic fungus Candida albicans, which use surface reductases to acquire iron from ferritin. In parasitic protozoa, there are practically no reports about the utilization of ferritin as a sole iron source. Trichomonas vaginalis uses ferritin iron but the mechanism by which it uptakes iron from this protein is still unknown. Recently, we reported that Entamoeba histolytica trophozoites endocytose ferritin by clathrin-coated pits and degrade this protein by means of specific cysteine proteases in the endosome/lysosome pathway. Concluding, pathogenic microorganisms capable of removing and acquiring iron from ferritin can obtain a plentiful source of this crucial metal to survive, colonize and invade the host. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Medical Cannabis: Clinical Practice
02.Hemorrhagic Shock: Recognition, Pathophysiology and Management
03.Patellofemoral Pain: An Evidence-Based Clinical Guide
04.Neanderthals in Plato’s Cave: A Relativistic Approach to Cultural Evolution
05.My Patients Were Mummies
06.‘L’Atelier Moderne’: An Exploration of the Collaborative Process Between Performer and Composer in Vocal Music Theatre of the 21st Century (CD Included)
07.The Voice at the End of the Telephone Line: The Psychology of Tele Carers
08.Caught up in the Spirit! Teaching for Womanist Liberation
09.The Transgender Handbook: A Guide for Transgender People, Their Families and Professionals
10.Mastering Science with Metacognitive and Self-Regulatory Strategies: A Teacher-Researcher Dialogue of Practical Applications for Adolescent Students
11.Political Migrations in Poland in the Period of World War II
12.Sociolinguistic Parallels Across Europe: Focus on Lowland Scotland and the Eastern Slavic Countries

Nova Science Publishers
© Copyright 2004 - 2017

Ferritin as an Iron Source for Pathogens (pp.1-46)