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01.Experimental Leukemia: History, Biology and Genetics
02.Cancer Metastasis Research: Pathological Insight
03.Eye Cancer Research Progress
04.Mesothelioma from Bench Side to Clinic
05.Photodynamic Therapy: New Research
06.Cancer and Stem Cells
07.Oncology Social Work Practice in the Care of Breast and Ovarian Cancer Survivors
08.Progress in Oral Cancer Research
09.New Research on Cutaneous Lymphomas
10.Aromatase Inhibitors: Types, Mode of Action and Indications
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Tamoxifen Concepts and Cancer: New Paradigms
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Editors: Ramon Andrade de Mello (Oncology Portuguese Institute of Porto Francisco Gentil, Department of Medical Oncology, Porto, Portugal)
Book Description:
Tamoxifen was first approved in 1977 and up to now remains a noteworthy therapeutic weapon to treat mainly breast cancer. However, further considerations exist regarding the tamoxifen profile. This book discusses recent research and future perspectives in the tamoxifen field. The topics discussed include tamoxifen pharmacokinetics, pharmacodynamics, adverse effects, clinical indications, therapeutic drug monitoring, autophagy mechanisms, tamoxifen topical formulation and breast cancer risk prevention, the use of tamoxifen in an estrogen-independent manner for various neoplasms (Hepatocellular carcinoma, renal cell carcinoma, high grade glioma), mechanisms of resistance, potential role of CYP2D6, tamoxifen and antidepressants interaction in a psychiatric view, obesity influence in tamoxifen treatment, electrical pulse-mediated tamoxifen delivery, and tamoxifen in melanoma treatment. (Imprint: Nova Biomedical)

Please click on a chapter below to purchase separately

Chapter 1 - Introduction to Tamoxifen in Novel Approaches (pp. 1-6)
Authors / Editors: (Ramon Andrade de Mello, Faculty of Medicine of the University of Porto, Porto, Portugal, and Department of Medical Oncology, Portuguese Oncology Institute, Porto, Portugal)

Chapter 2 - Tamoxifen Metabolism and Biological Activity (pp. 7-28)
Authors / Editors: (Jennifer Gjerde, Line L. Haugan Moi, Gunnar Mellgren, and Ernst A. Lien, Institute of Medicine, University of Bergen and The Hormone Laboratory, Haukeland University Hospital, Bergen and Department of Clinical Pathology, The University Hospital of North Norway, Norway)
***Open Access Chapter. Free Download Available***

Chapter 3 - Tamoxifen and Autophagy: To Cease and Resist? (L. Phan, S.M. Gorski, Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada)(pp. 29
Authors / Editors:
***Open Access Chapter. Free Download Available***

Chapter 4 - Ecotoxicological Effects of Tamoxifen in the Aquatic Environment (pp. 47-60)
Authors / Editors: (Liwei Sun, Jian Chi, Xinhua Hu, Zhengwei Fu, College of Biological and Environmental Engineering, Zhejiang University of Technology, District, Zhaohui, Hangzhou, Zhejiang, China)

Chapter 5 - Innovative Approaches to Tamoxifen Administration for Breast Cancer Prevention (pp. 61-86)
Authors / Editors: (Brandy M. Heckman-Stoddard, Oukseub Lee, Matteo Lazzeroni, Seema Khan, Andrea DeCensi, and Barbara K. Dunn, NCI Division of Cancer Prevention, Basic Prevention Science Research Group, Bethesda, Maryland, USA, and others)

Chapter 6 - The Use of Tamoxifen in an Estrogen-Independent Manner for Various Neoplasms (pp. 87-94)
Authors / Editors: (Andrew Trister, Shilpen Patel, University of Washington, Department of Radiation Oncology, USA)

Chapter 7 - Tamoxifen: More than an ER Antagonist (pp. 95-112)
Authors / Editors: (D.H. McGuinness and J. Edwards, Institute of Cancer, College of Medical Veterinary and Life Sciences, McGregor Building, Western Infirmary, Glasgow, Scotland)

Chapter 8 - Tamoxifen: Biological Activities and Therapeutic Outcomes (pp. 113-134)
Authors / Editors: (Peter G. Bradford and Atif B. Awad, State University of New York at Buffalo, Buffalo, New York, USA)

Chapter 9 - The Role of Pharmacogenomics in Personalizing the Use of Tamoxifen in Breast Cancer (pp. 135-146)
Authors / Editors: (S.J. Johnston, L.C. Chen, and K.L. Cheung, Division of Breast Surgery and School of Pharmacy, University of Nottingham, UK)

Chapter 10 - Tamoxifen and Antidepressants in the Breast Cancer Setting (pp. 147-152)
Authors / Editors: (Alber Morais Dias, Service of Psychiatry, Sao Paulo State Court of Justice, São Paulo, Brazil)

Chapter 11 - Obesity in Breast Cancer Treated with Tamoxifen (pp. 153-162)
Authors / Editors: (Karla Sanchéz-Lara and Jenny G. Turcott, Oncology Center, Médica Sur, Thoracic Oncology Clinic, Instituto Nacional de Cancerología de México (INCan), Mexico City, Mexico)

Chapter 12 - Electrically Enhanced Tamoxifen Delivery for Breast Cancer Treatments (pp. 163-178)
Authors / Editors: (Ignacio G. Camarillo, Maxine Nichols, Funian Xiao, Therese Salameh, Arutselvan Natarajan, Ganesh Venkatraman, and Raji Sundararajan, Purdue University, West Lafayette, Indiana, USA, and Stanford Medical School, California, USA)

Chapter 13 - Tamoxifen and Melanoma (pp. 179-196)
Authors / Editors: (Julieta Ruiz Beguerie, School of Public Health, University of Sydney, Australia)

      Cancer Etiology, Diagnosis and Treatments
      Pharmacology - Research, Safety Testing and Regulation
   Binding: Hardcover
   Pub. Date: 2012- December
   Pages: 222, 7x10 - (NBC-C)
   ISBN: 978-1-62081-520-5
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Tamoxifen Concepts and Cancer: New Paradigms