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01.Gene Silencing: New Research
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04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
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MicroRNA let-7: Role in Human Diseases and Drug Discovery
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Editors: Neetu Dahiya (University of Virginia, Charlottesville)
Book Description:
MicroRNAs are small non-coding RNAs involved in posttranscriptional regulation of gene expression. Thousands of miRNAs have been identified in different organisms including viruses, insects, plants and animals. MiRNAs has emerged as key regulators of important biological processes. The differential expression of miRNAs in various human diseases has made them potential candidates for developing novel therapies and personalized medicines. This book is focused on microRNA let-7, the second miRNA discovered in the year 2000 and one of the most studied miRNA. This book discusses various aspects of miRNA let-7 starting from its discovery, biogenesis, transcriptional and posttranscriptional regulation to its crucial role in various fundamental cellular processes such as development, stem cell maintenance and differentiation, regulation of signaling pathways in cancer, drug resistance and therapeutic potential in different human diseases. (Imprint: Nova Biomedical)

Please click on a chapter below to purchase separately

Chapter 1 - MicroRNA let-7: Discovery, Biogenesis, and General Function (pp.1-10)
Authors / Editors: (Cheng-Chia Yu)

Chapter 2 - Transcriptional and post-transcriptional regulation of let-7 (pp.11-24)
Authors / Editors: (Monika Sangwan, Neetu Dahiya)

Chapter 3 - Let-7 and signaling pathways in cancers (pp.25-42)
Authors / Editors: (Yuanjia Tang, Nan Shen)

Chapter 4 - Role of let-7 networks in stem cell maintenance and differentiation (pp.43-56)
Authors / Editors: (Candida Vaz, Vivek Tanavde)
***Open Access Chapter. Free Download Available***

Chapter 5 - The role of microRNA let-7 in stem/progenitor cells (pp.57-74)
Authors / Editors: (Shao-Chih Chiu, Shinn-Zong Lin)

Chapter 6 - The impact of the let-7 family on resistance to anticancer treatment (pp.75-88)
Authors / Editors: (Mathias Fritz, Damian J. Hussey, Joerg Haier, Richard.Hummel)

Chapter 7 - Therapeutic Potential of miRNA let-7 in Human Diseases (pp.89-108)
Authors / Editors: (Lu Elean Wang, Xu-Hui Li, Zhi Rong Qian)

Chapter 8 - Let-7 and Cancer (pp.109-124)
Authors / Editors: (Cesar Seigi Fuziwara, Murilo Vieira Geraldo and Edna Teruko Kimura)

Chapter 9 - Roles of let-7 family miRNAs in development and differentiation (pp.125-144)
Authors / Editors: (Rikako Sanuki, Takahisa Furukawa)
***Open Access Chapter. Free Download Available***

   Series:
      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
      Genetics - Research and Issues
   Binding: Hardcover
   Pub. Date: 2013- January
   Pages: 164, 6 x 9 (NBC - C)
   ISBN: 978-1-62081-152-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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MicroRNA let-7: Role in Human Diseases and Drug Discovery