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Medicine Research Summaries. Volume 20
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01.Ecotoxicology of Free-Living Soil Nematode Caenorhabditis elegans pp. 1-52
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Neurotoxicological Effects of Aeration Lagoons Effluents for the Treatment of Domestic and Hospital Wastewaters on Elliptio complanata pp. 263-282 $100.00
Authors:  (F. Gagné, C. André, B. Bouchard, M. Fournier, C. Gagnon, Fluvial Ecosystem Research Section, Environment Canada, Montréal, Quebec, Canada, and others)
Abstract:
The purpose of this study was to examine the neuroendocrine-disrupting effects of an effluent from aeration lagoons treating a mixture of domestic and hospital wastewater on endemic freshwater mussels. Elliptio complanata mussels were caged within the final aeration lagoon and at two other sites located 1 km downstream and 1 km upstream of the effluent dispersal plume in the receiving river for 14 days. After the exposure period, the mussels were analyzed for vitellogenin-like proteins (a measure of estrogenicity), dehydrofolate reductase activity (DNA precursor metabolite), stress biomarkers (lipid peroxidation and genotoxicity) and neuroendocrine status as determined by monoamines (dopamine and serotonin), glutamate, monoamine oxidase and acetylcholinesterase activities. The effluent contained significant amounts of pharmaceutical products such as ibuprofen, trimethoprim, carbamazepine, naproxen and various quinoline antibiotics. Vitellogenin-like proteins and dehydrofolate reductase (inhibited by the bacteriostatic trimethoprim) activity were respectively induced and inhibited by the effluent, indicating estrogenicity and inhibition of DNA precursors biosynthesis. Mussels exposed to the effluents contained very high amounts of dopamine and decreased monoamine oxidase activity. Mussels caged inside the aeration lagoon showed lower lipid peroxidation and higher DNA strand breaks; the latter was also true of mussels at the site downstream of the effluent dispersion outfall. A multivariate analysis revealed that the lagoon and downstream sites were easily distinguished from the upstream site and the following biomarkers explained most of the data responses: glutamate, DNA damage in gills, dopamine, dehydrofolate reductase and acetylcholinesterase. In conclusion, the effluent from the last aeration lagoons for the treatment of domestic and hospital wastewaters is deleterious, estrogenic and disruptive to the metabolism of dopamine, glutamate and the cholinergic system in freshwater mussels. 


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Neurotoxicological Effects of Aeration Lagoons Effluents for the Treatment of Domestic and Hospital Wastewaters on Elliptio complanata pp. 263-282