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Medicine Research Summaries. Volume 16
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01.Ecotoxicology of Free-Living Soil Nematode Caenorhabditis elegans pp. 1-52
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Ecotoxicology of Free-Living Soil Nematode Caenorhabditis elegans pp. 1-52 $100.00
Authors:  (Toshihiko Eki, Division of Bioscience and Biotechnology, Department of Environmental and Life Sciences, Toyohashi University of Technology, Toyohashi, Aichi, Japan)
Abstract:
The free-living nematode Caenorhabditis elegans (C. elegans) is a ubiquitous soil organism that plays a primary role in decomposition and nutrient recycling in the soil ecosystem. C. elegans is widely used as a model for studying fundamental processes of multicellular eukaryotes, due to its easy maintenance and handling in the laboratory. Because of these properties, several toxicity tests using C. elegans have been developed for ecological risk assessment. In these tests, several endpoints, including mortality, reproduction, growth, behavior, lifespan, and inductions of stress-response genes, are used to detect ecotoxicity of a variety of agents, such as metals, detergents, pesticides, and endocrine disrupting chemicals. This chapter describes the effects of various ecotoxicants on nematodes; ecotoxicity tests using C. elegans, including transgenic nematodes; and recent progress in C. elegans-based technology with regard to ecotoxicology, such as ecotoxicogenomics and high-throughput toxicity assays. 


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Ecotoxicology of Free-Living Soil Nematode Caenorhabditis elegans pp. 1-52