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01.Eosinophils: Structure, Biological Properties and Role in Disease
02.Regulatory T Cells
03.Immunosuppression: New Research
04.Lupus Renal Involvement: A Case-Based Atlas
05.Mannose-Binding Lectin in the Innate Immune System
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Mannose-Binding Lectin in the Innate Immune System $49.00
Authors: Iara de Messias-Reason and Angelica B. W. Boldt (Molecular and Immunopathology Laboratory, Department of Medical Pathology, Federal University of ParanŠ, Curitiba, Brazil) 
Book Description:
Mannose-binding lectin (MBL) is a plasma protein with an important role in the innate immune system. MBL recognizes pathogens through carbohydrate structures present on the surface of a range of pathogenic organisms including viruses, bacteria, fungi and protozoans. These structures may be referred to as pathogen-associated molecular patterns (PAMPs). After binding to PAMPs, MBL promotes C1- and antibody-independent activation of complement, leading to complement-mediated killing and/or phagocytosis. MBL is also known to modulate the secretion of cytokines from macrophages and to mediate the clearance of apoptotic cells as such playing a role in the inflammatory response. This book summarizes the actual understanding of human MBL biology and introduces the general aspects of the structure, function and genetics of MBL, as well as an analysis of the role of MBL in the predisposition to clinically relevant diseases.

Table of Contents:


Association with Diseases



   Binding: ebook
   Pub. Date: 2009 - 2nd Quarter
   Pages: 89 pp.
   ISBN: 978-1-61470-207-8
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Mannose-Binding Lectin in the Innate Immune System