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Preparation of polymer composite nanofibers by electrospinning and their biomedical application pp.755-806 $100.00
Authors:  (K M Kamruzzaman Selim and Inn-Kyu Kang, Department of Polymer Science and Engineering, Kyungpook National University, Daegu, Republic of Korea)
Electrospinning is one of the most promising fabrication methods designed to form
ultra-fine fiber with diameters ranging from several micrometers to tens of nanometers.
The electrospun fibers have two unique features that make it well suited to biomedical
applications. Firstly, they can mimic the structure of extracellular matrices (ECM), which
are composed of randomly oriented collagens. Secondly, the electrospun fibrous scaffold
has a highly porous structure that is desirable, because it allows for cell seeding or
migration. The electrospinning technique can be used in biomedical applications to
construct wound dressings, drug-delivery platforms, and tissue engineering scaffolds. In
this chapter, the basic concept of the electrospinning technique, especially its uses
regarding the fabrication of polymer nanofibrous scaffolds, is described, focusing on the
preparation of polymer nanocomposites by immobilization of biomolecules or
biocompatible materials on the surface of the nanofibers through blending or chemical
cross-linking methods. After interaction of as-prepared biomolecules-containing
nanofibers with cells, the morphological and biological phenomena of polymer
composites are comprehensively reviewed based on selective research studies. In
addition, the use of prepared nanocomposites in regards to biomedical fields has been
concisely demonstrated. The present review suggests that very straight and biocompatible
nanocomposites can be prepared by immobilizing natural biopolymers, such as collagen,
gelatin, keratin etc., or other biocompatible materials, such as hydroxyapatite, silver
nanoparticles on biodegradable synthetic electrospun polymers such as poly(lactic acid)
(PLA), poly(glycolic acid)(PGA), poly(lactide-co-glycolide) (PLGA), poly(ε-
caprolactone) (PCL), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), etc. The
biomolecules-containing polymer nanocomposites exhibited higher cell adhesion,
proliferation, and cell viability in comparison to non-conjugated nanofibers. The
nanocomposites prepared by electrospinning have a potential for use in regards to tissue
engineering, wound dressing, and other biomedical applications. 

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Preparation of polymer composite nanofibers by electrospinning and their biomedical application pp.755-806