Collagen Composites for Tissue Engineering pp.145-178
Authors: (Chaoliang He, Fengfu Li, May Griffith, University of Ottawa Eye Institute and Ottawa Health Research Institute, Ottawa, Ontario, Canada)
Abstract: In recent years, the field of tissue engineering has been developed aiming to meet the tremendous need for transplantation of organs and tissues. In a general sense, tissue engineering seeks to fabricate living replacement parts for the body. Strategies currently used to engineer tissues depend on employing a material to support cell growth and tissue regeneration. These scaffolds are mostly based on extracellular matrix materials, mainly collagen and its composites. In this chapter, the preparation, properties and application of all kinds of collagen composites including our own work are reviewed. Collagen forms composites with a variety of materials such as naturally derived polymers, synthetic polymers, fibers and microparticles for tissue engineering. The purpose of fabrication of collagen composites mainly lies in that the resulting composite materials would provide better biocompatibility, cell-scaffold interaction or enhancement of mechanical properties of individual polymers. Overall, collagen composite scaffolds have played and will still play an important role in the field of tissue engineering.