Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Infection » E. coli Infections: Causes, Treatment and Prevention Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Native Americans: Developments, Policies and Research. Volume 5
$145.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Uropathogenic Escherichia coli: The Pre-Eminent Urinary Tract Infection Pathogen pp. 1-66
Tell A Friend
 
Tell someone you know about this product.
Uropathogenic Escherichia coli: The Pre-Eminent Urinary Tract Infection Pathogen pp. 1-66 $0.00
Authors:  (David W. Hilbert, Women’s Health Research Center, Medical Diagnostic Laboratories, Hamilton, New Jersey, USA)
Abstract:
Community-acquired urinary tract infections (UTIs) are a major health problem, largely affecting women. In the United States, 11% of women suffer a UTI each year, and 60% of women experience at least one UTI during their lifetime. Recurrence is common, with 44% of patients suffering another infection within 1 year. Most infections remain confined to the bladder and cause painful and urgent urination (cystitis), although some patients are colonized asymptomatically. In a subset of infections, the pathogen ascends to the kidneys, resulting in pyelonephritis, a serious and life-threatening condition. Uropathogenic Escherichia coli (UPEC) is responsible for >80% of community-acquired UTIs. UPEC originate in the gastrointestinal (GI) tract and are transmitted to the urinary tract via colonization of the vagina and periurethral area. UPEC utilizes a number of virulence factors to colonize the urinary tract, including fimbriae to adhere to and invade the bladder epithelium, siderophores to scavenge iron, and toxins to modify host cell signaling. These virulence factors are required to overcome the formidable innate immune defenses of the bladder. Toll-like Receptors (TLRs), especially TLR4, sense UPEC and trigger a multifaceted response to combat the infection, including secretion of chemokines to recruit neutrophils, antimicrobial peptide (AMP) secretion and exfoliation of the bladder epithelium. The sequencing of UPEC genomes has revealed a highly mosaic structure with numerous pathogenicity islands (PAIs) integrated at multiple sites in the genome. In addition, comparative genomics has revealed a close relationship between UPEC and other pathogenic E. coli, including strains that cause avian colibacillosis and neonatal meningitis. Although most UTIs can be treated with standard antimicrobial therapy, resistance to these agents is rising. The search for new therapies has led to both the innovation of novel molecules to inhibit UPEC adherence as well as the revisiting of older agents such as fosfomycin. Prevention of UTIs has focused on cranberry consumption and the use of probiotics to prevent vaginal colonization by UPEC. Lastly, progress has been made on development of a vaccine to prevent UTIs. In summary, UTIs caused by E. coli are a major health problem, with researchers using a multidisciplinary approach to improve prevention and therapy. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Returning to Spirituality
02.Parenting: Cultural Influences and Impact on Childhood Health and Well-Being
03.Food Production and Eating Habits From Around the World: A Multidisciplinary Approach
04.Evidence-Based Cosmetic Surgery
05.Alternative Medicine Research Yearbook 2014
06.Cholangiocarcinoma
07.Experimental Models in Glioblastoma Research
08.Essentials of Chronic Kidney Disease
09.Collaborative Learning: Developments in Research and Practice
10.Sustainable Development: Processes, Challenges and Prospects
11.Advances in Sociology Research. Volume 16
12.Gibberellins and Gibberellic Acid: Biosynthesis, Regulation and Physiological Effects

Nova Science Publishers
© Copyright 2004 - 2015

Uropathogenic Escherichia coli: The Pre-Eminent Urinary Tract Infection Pathogen pp. 1-66