Selective Toxicity of Pycnogenol® for Malignant Ovarian Germ Cells In Vitro (pp. 207-212)
Authors: Amber R. Buz’Zard, Benjamin H.S. Lau (School of Medicine, Loma Linda University)
Abstract: Ovarian cancer is the sixth most common cancer in women and accounts for more deaths than any other cancer of the female reproductive system. Chemoprevention is regarded as an efficient strategy to prevent cancer. The most useful cancer chemopreventive compounds will have minimal long-term toxicity, while significantly reducing cancer incidence, delaying cancer onset or preventing cancer progression. Pycnogenol® (Pyc) is a proprietary mixture of water-soluble bioflavonoids extracted from the bark of the French maritime pine. Human ovarian cell lines (normal, benign and malignant) were incubated with Pyc and prepared for cell viability and apoptosis assays. Our data show that Pyc is selectively toxic for malignant ovarian germ cells in vitro and suggest that it may be a potential chemopreventative agent against ovarian cancer.