Abstract: The research question for the Cochrane Nursing Care Field (CNCF) was if diclofenac decrease acute pain and post-administration adverse effects in children compared to a placebo or any other treatment? The review revealed that Diclofenac was effective in treating acute post-operative pain in children. When given during the peri-operative period, Diclofenac significantly decreased the number of children requiring additional pain medication by half, and significantly reduced the incidence of nausea and/or vomiting. Diclofenac was twice as effective as Paracetamol for pediatric surgical pain, and while it causes similar types of serious adverse reactions as in adults, they are rare and occur in fewer than 3 in 1,000 children who received the drug. Intramuscular injections should be avoided due to the risk of serious injection site tissue damage. More research is recommended to determine optimal dosing in children, as this aspect of drug administration was not a focus of any of the studies.