Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Most recent entries » Horizons in World Cardiovascular Research. Volume 2 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Dehydrogenases: Biochemistry, Functions and Role in Disease
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Beneficial Clinical Effects of Perhexiline in Cardiac Patients: Multiple Biochemical Mechanisms, pp. 1-27
Tell A Friend
Tell someone you know about this product.
Beneficial Clinical Effects of Perhexiline in Cardiac Patients: Multiple Biochemical Mechanisms, pp. 1-27 $100.00
Authors:  (Yuliy Y. Chirkov, Aaron L. Sverdlov, John D. Horowitz, Basil Hetzel Institute, The Queen Elizabeth Hospital/Dept. of Medicine, The University of Adelaide, Australia)
Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as a prophylactic anti-anginal drug in the late 1960s. It was initially a popular and effective treatment for angina, having the almost unique property compared to other agents available at that time, of not inducing reductions in blood pressure or heart rate. Despite the initial success, its use diminished markedly due to the occurrence during long-term therapy of poorly understood side effects (neurotoxicity and hepatotoxicity), which later were shown to be associated with high plasma concentrations of perhexiline, occurring in patients with relatively slow hepatic metabolism of the drug. However, therapeutic plasma monitoring and associated dose adjustments have led to perhexiline's reintroduction into clinical practice. Recent clinical data have proved its safety and
maintained efficacy. Perhexiline reduced anginal frequency in patients with refractory angina. In patients with chronic heart failure, perhexiline improved peak exercise oxygen consumption, left ventricular ejection fraction, symptoms, resting and peak stress
myocardial function. Perhexiline also appears to be effective in suppressing symptoms in patients with acute coronary syndromes or with advanced and inoperable aortic valvular stenosis. Herein we discuss perhexiline's pharmacology with particular emphasis on its
mechanism(s) of action. 

Available Options:
Special Focus Titles
01.Chinese Civilization in the 21st Century
02.Conflict and Communication: A Changing Asia in a Globalizing World - Social and Political Perspectives
03.True Islam, Jihad, and Terrorism: The Science of Islamic Foreign Policy
04.The Family Doctors: Images and Metaphors of the Family Doctor to Learn Family Medicine
05.International Book of Erectile Dysfunction
06.Post-Acute and Long Term Geriatric Care Clinical Advisor. Volume II
07.Intelligent Tutoring Systems: Structure, Applications and Challenges
08.Knowledge Creation: Going Beyond Published Financial Information
09.Theory of the Integer and Fractional Quantum Hall Effects
10.Geographic Distribution, Ecological Impact, and Conservation Strategies for North American Crayfish
11.Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits. Volume 6
12.Innovative Bio-Products for Agriculture: Pig Manure Utilization and Treatment

Nova Science Publishers
© Copyright 2004 - 2016

Beneficial Clinical Effects of Perhexiline in Cardiac Patients: Multiple Biochemical Mechanisms, pp. 1-27