Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Journals » Journal of Pain Management » Volume 4 Issue 4 Articles » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Infrastructure Investments: Politics, Barriers and Economic Consequences
$100.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Bestsellers
01.Systematic Review of Data from Randomized Controlled Trials on the Efficacy, Safety and Tolerability of Drugs Used to Treat Painful Diabetic Neuropathy
02.Total Pain Concept: Multisensory Stimulation, Exercise Therapy and Coping Skill Training for Community-dwelling Older Persons with Chronic Pain
03.Oxycodone or Oxycodone Plus Paracetamol for Acute Postoperative Pain in Adults
04.Parental Experiences of Pediatric Chronic Pain Managemnent Services
05.Oral Paracetamol (Acetaminophen) with Codeine for Postoperative Pain in Adults
06.Pathological Fracture of the Tibia in a Patient with Invasive Ductal Carcinoma of the Breast: A Case Report of a Rare Finding
07.Transcutaneous Electrostimulation for Osteoarthritis of the Knee
08.What is the Role of Decision Making and Patient Choice on Chronic Pain Patients’ Psychological Well-being During a Residential Chronic Pain Management Programme?
Notifications more
NotificationsNotify me of updates to Systematic Review of Data from Randomized Controlled Trials on the Efficacy, Safety and Tolerability of Drugs Used to Treat Painful Diabetic Neuropathy
Tell A Friend
 
Tell someone you know about this product.
Systematic Review of Data from Randomized Controlled Trials on the Efficacy, Safety and Tolerability of Drugs Used to Treat Painful Diabetic Neuropathy $43.00
Authors:  John Edelsberg, Claudia Lord and Gerry Oster
Abstract:
Numerous drugs are used in clinical practice to treat patients with painful diabetic peripheral neuropathy (DPN). Their comparative efficacy, safety, and tolerability have not been well-documented. Objective. To evaluate systematically data from reports of placebo-controlled randomized trials (RCTs) on the efficacy, safety, and tolerability of drugs used to treat painful DPN. Methods. Using data from all published English-language reports of placebo-controlled RCTs of drugs for painful DPN, we compiled information on: (1) placebo-corrected % reduction in pain intensity from randomization to end of active treatment; (2) relative risk (RR) of withdrawal due to lack of efficacy; (3) RR of adverse events (AEs); and (4) RR of withdrawal due to AEs. When estimates were available from more than one trial for a given agent, we pooled data using meta-analysis. Significance of treatment effects versus placebo was based on Z scores. Results. We identified 31 RCTs evaluating 14 different drugs in patients with painful DPN. Most trials were small (<200 patients). All agents were found to significantly reduce pain intensity (range: 8.0% [oxcarbazepine] to 26.4% [CR oxycodone]). RR of withdrawal due to lack of efficacy was significantly lower only for CR oxycodone and tramadol. Analysis of AEs was hampered by spotty and inconsistent reporting and wide variation in sample sizes. Conclusion. While all drugs that we examined were efficacious in painful DPN, available trial data provide only limited guidance regarding optimal therapy, due to small sample sizes, incomplete reporting of AEs, and no published reports of placebo-controlled RCTs of tricyclic antidepressants. 


Available Options:
Version:
Customers who bought this product also purchased

Oxycodone or Oxycodone Plus Paracetamol for Acute Postoperative Pain in Adults

Oral Paracetamol (Acetaminophen) with Codeine for Postoperative Pain in Adults
Special Focus Titles
01.Heart Failure: What a Non-Heart Failure Specialist Needs to Know
02.Bottle-Feeding: Perceptions, Practices, and Health Outcomes
03.Between Success and Failure: Assessment of Aspirations and Risk (CD Included)
04.Understanding Left and Right: An Illustrated Guide to the Political Divide
05.Phytoremediation: Methods, Management and Assessment
06.“Waste-to-Profit” (W-t-P): Value added Products to Generate Wealth for a Sustainable Economy. Volume 1
07.The Impact and Implications of Crisis: A Comprehensive Approach Combining Elements of Health and Society
08.When "We" Are Stressed: A Dyadic Approach to Coping with Stressful Events
09.The Man Brand: Why Public Campaigns Hide Half of Intimate Partner Violence
10.The Life of Abraham Lincoln: Drawn from Original Sources and Containing Many Speeches, Letters and Telegrams Hitherto Unpublished. Volume One
11.Life of Charles Dickens
12.The Inventions and Discoveries of the World’s Most Famous Scientists

Nova Science Publishers
© Copyright 2004 - 2018

Systematic Review of Data from Randomized Controlled Trials on the Efficacy, Safety and Tolerability of Drugs Used to Treat Painful Diabetic Neuropathy