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Comparative Study of the Suppression on T-Cell and Dendritic Cells in a Mathematical Model of Psoriasis $43.00
Authors:  Priti Kumar Roy and Jhumpa Bhadra
Abstract:
Psoriasis is a common T-Cell mediated inflammatory chronic skin disease. The reddish, scaly plaque formed in psoriasis is characterized by hy-perproliferation of epidermal Keratinocytes. The immune system play an im¬portant role in the pathogenesis of Psoriasis. Clinical researches show both genetic and environmental triggers are responsible for the development of Psoriasis. Also Keratinocytes together with excessive nitric oxide are one causal to the Psoriatic lesions. Here we consider a mathematical model for the disease Psoriasis, consists of a set of differential equations involving the T-Lymphocytes cells, Dendritic Cells/Macrophages and the epidermal Ker¬atinocytes. Cell biological research on Psoriasis so far established that sup¬pression of epidermal T-cell density inhibits Psoriatic pathogenesis. We im¬plement such T-cell suppression in our mathematical model. Also we observe the dynamical behavior of the system if the suppression can be made on Den¬dritic cells. Our comparative analysis shows that a suppressed epidermal T-cell and DCs density drastically reduces Keratinocytes densities, which signifies an eventual inhibition of Psoriatic pathogenesis.



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Comparative Study of the Suppression on T-Cell and Dendritic Cells in a Mathematical Model of Psoriasis