Collagen Changes in the Extracellular Matrix of Tumor-Affected Human Breast: A Tale of OF/LB and Type V Collagens, pp. 117-137
Authors: Claudio Luparello, Dipartimento di Biologia Cellulare e dello Sviluppo, UniversitÓ, Viale delle Scienze, Palermo, Italy
Abstract: It is widely acknowledged that the extracellular matrix (ECM) of connective tissues plays active roles in numerous biological processes such as cell differentiation, life/death promotion and carcinogenesis. Ductal infiltrating carcinoma (DIC) of the breast is a highly metastatic tumor histotype commonly associated with drastic massive alterations of ECM architecture and composition, especially concerning its collagenous component. In particular, it was demonstrated that the stroma of DIC of the human breast contains a considerable amount of an embryo-foetal collagen type (OF/LB), while type V collagen, which is a minor component of normal human breast ECM, undergoes over-deposition in the affected gland. In vitro studies indicated that substrates made from these collagen species were able to exert a marked and opposite effect on viability, proliferation and invasiveness of DIC-derived breast cancer cell lines. In this chapter, we will summarize and discuss the studies on OF/ LB and type V collagens and their putative relevance in DIC ingrowth.