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Collagen Changes in the Extracellular Matrix of Tumor-Affected Human Breast: A Tale of OF/LB and Type V Collagens, pp. 117-137 $100.00
Authors:  Claudio Luparello, Dipartimento di Biologia Cellulare e dello Sviluppo, Università, Viale delle Scienze, Palermo, Italy
Abstract:
It is widely acknowledged that the extracellular matrix (ECM) of
connective tissues plays active roles in numerous biological processes
such as cell differentiation, life/death promotion and carcinogenesis.
Ductal infiltrating carcinoma (DIC) of the breast is a highly metastatic
tumor histotype commonly associated with drastic massive alterations of
ECM architecture and composition, especially concerning its collagenous
component. In particular, it was demonstrated that the stroma of DIC of
the human breast contains a considerable amount of an embryo-foetal
collagen type (OF/LB), while type V collagen, which is a minor
component of normal human breast ECM, undergoes over-deposition in
the affected gland. In vitro studies indicated that substrates made from
these collagen species were able to exert a marked and opposite effect on
viability, proliferation and invasiveness of DIC-derived breast cancer cell
lines. In this chapter, we will summarize and discuss the studies on OF/
LB and type V collagens and their putative relevance in DIC ingrowth. 


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Collagen Changes in the Extracellular Matrix of Tumor-Affected Human Breast: A Tale of OF/LB and Type V Collagens, pp. 117-137