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The Evolving Role of Molecular Markers in the Diagnosis of Breast Cancer pp. 89-116 $100.00
Authors:  Danh Tran-Thanh, Susan J. Done, Department of Pathology, University Health Network, Toronto, Ontario, Canada and others
Abstract:
Accurate pathological assessment is at the center of the diagnosis of
breast cancer. This article will review current standards of pathological
assessment of breast cancer specimens. Currently, the most widely
employed molecular tests are immunohistochemical assessments of
hormone receptor and HER-2 receptor status. With advances in
molecular biology our understanding of the development of breast cancer
is changing. There will be a discussion of recent molecular profiling
studies in breast cancer and how our view of the classification of breast
cancer is changing. The current role of molecular tests in the
management of breast cancer will be addressed, highlighting their
strengths and limitations. Desirable attributes for new markers will be
presented. Going forward it is important that new tests do more than
reinforce the information we have already but add additional information
to each case. Finally, a vision of the role of molecular pathology in breast
cancer management in the future will be presented. 


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The Evolving Role of Molecular Markers in the Diagnosis of Breast Cancer pp. 89-116