Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Journals » Journal of Pain Management » Volume 1 Issue 3 Articles » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Emerging Materials for Environment Protection and Renewable Energy
$207.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Function of Potassium Channels in Blood Mononuclear Cells of Patients with Fibromyalgia (pp. 289-293)
Tell A Friend
 
Tell someone you know about this product.
Function of Potassium Channels in Blood Mononuclear Cells of Patients with Fibromyalgia (pp. 289-293) $43.00
Authors:  Kim Lawson, Elisabeth Shawcross and Jon H Raphael
Abstract:
K+ channel function, which has been associated with modulation of chronic pain conditions, is abnormal in peripheral blood mononuclear cells (PBMC) of patients with neuropathic pain. Therefore, K+ channel activity and sensitivity of their function to selective K+ channel blockers was investigated in isolated PBMC of patients with fibromyalgia compared with that of controls. K+ channel activity was determined, using a Rb+ efflux assay, in PBMC from 13 patients with fibromyalgia and compared with results from 14 healthy controls and nine cardiovascular medical controls. K+ channels were stimulated by KCl-induced membrane depolarization and characterized using the K+ channel blockers, margatoxin and charybdotoxin. Increasing the extracellular KCl concentration augmented the Rb+ efflux in all groups. The stimulated Rb+ efflux did not differ among patients with fibromyalgia (34.7 ± 3.5%) and healthy controls (33.5 ± 3.0%), but responses from samples of medical controls (45.8 ± 3.8%) were greater than those of healthy controls (P < 0.05), but not fibromyalgia patients. Exposure of the PBMC to the K+ channel blockers, margatoxin and charybdotoxin, did not change the between-group comparisons of the data. These data indicate that the K+ channel activity in PBMC from patients with fibromyalgia did not differ from that observed in cells from healthy controls, in contrast to that previously reported for patients with neuropathic pain conditions. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Heart Failure: What a Non-Heart Failure Specialist Needs to Know
02.Bottle-Feeding: Perceptions, Practices, and Health Outcomes
03.Between Success and Failure: Assessment of Aspirations and Risk (CD Included)
04.Understanding Left and Right: An Illustrated Guide to the Political Divide
05.Phytoremediation: Methods, Management and Assessment
06.“Waste-to-Profit” (W-t-P): Value added Products to Generate Wealth for a Sustainable Economy. Volume 1
07.The Impact and Implications of Crisis: A Comprehensive Approach Combining Elements of Health and Society
08.When "We" Are Stressed: A Dyadic Approach to Coping with Stressful Events
09.The Man Brand: Why Public Campaigns Hide Half of Intimate Partner Violence
10.The Life of Abraham Lincoln: Drawn from Original Sources and Containing Many Speeches, Letters and Telegrams Hitherto Unpublished. Volume One
11.Life of Charles Dickens
12.The Inventions and Discoveries of the World’s Most Famous Scientists

Nova Science Publishers
© Copyright 2004 - 2018

Function of Potassium Channels in Blood Mononuclear Cells of Patients with Fibromyalgia (pp. 289-293)