Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Journals » Journal of Pain Management » Volume 1 Issue 1 Articles » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
U.S. Financial Regulatory Structure: Overview, Complexities, and the Effects of Fragmentation and Overlap
$150.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48)
Tell A Friend
 
Tell someone you know about this product.
Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48) $43.00
Authors:  Kim Lawson, Elisabeth Shawcross and Jon H. Raphael
Abstract:
A reduced functioning of lymphocytes, where K+ channels play a fundamental role, has been reported in chronic pain conditions. We have therefore investigated the K+ channel activity in isolated lymphocytes of patients with complex regional pain syndrome (CRPS) or localised neuropathic pain (LNP) conditions compared with that of controls. K+ channel activity was determined using a Rb+ efflux assay in the lymphocytes from nine patients with CRPS and 13 patients with LNP and compared with results from 14 healthy controls and nine medical controls. K+ channels were stimulated by KCl-induced membrane depolarization and characterized using the K+ channel blockers, margatoxin and charybdotoxin. Increasing the extracellular KCl concentration augmented the Rb+ efflux in all groups. The stimulated Rb+ efflux from lymphocytes of the medical and healthy controls was significantly attenuated by margatoxin (10 nM) alone and in combination with charybdotoxin (100 nM). In contrast, the Rb+ efflux from lymphocytes of patients with CRPS or LNP was not modified by either treatment. The Rb+ efflux from lymphocytes of healthy controls was significantly lower than that of the other groups. The K+ channel blockers increased the level of significance relative to the CRPS and LNP groups, but decreased the level of significance relative to the medical controls. These findings are consistent with an abnormal functioning of K+ channels in lymphocytes from patients with CRPS or LNP, which may be relevant to the pain in these conditions. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Surgery of the Orbital Cavity: “No-Man's-Land”
02.Public Health: Some International Aspects
03.Diets and Diseases: Causes and Prevention
04.Strategic Intervention: What to Do When Things Go Wrong
05.Lifelong Learning: Concepts, Benefits and Challenges
06.Ageing Disgracefully, with Grace: Enjoying Growing Older
07.Information Literacy Education in Japanese Libraries for Lifelong Learning
08.Music Therapy in the Management of Medical Conditions
09.Cultural Theory for the Humanities
10.Grape Seeds: Nutrient Content, Antioxidant Properties and Health Benefits
11.Ecological Restoration: Global Challenges, Social Aspects and Environmental Benefits
12.Comparative Effectiveness Research (CER): New Methods, Challenges and Health Implications

Nova Science Publishers
© Copyright 2004 - 2016

Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48)