Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Journals » Journal of Pain Management » Volume 1 Issue 1 Articles » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Federal Use of Confidential Informants: Analysis and Guidelines
$108.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48)
Tell A Friend
 
Tell someone you know about this product.
Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48) $43.00
Authors:  Kim Lawson, Elisabeth Shawcross and Jon H. Raphael
Abstract:
A reduced functioning of lymphocytes, where K+ channels play a fundamental role, has been reported in chronic pain conditions. We have therefore investigated the K+ channel activity in isolated lymphocytes of patients with complex regional pain syndrome (CRPS) or localised neuropathic pain (LNP) conditions compared with that of controls. K+ channel activity was determined using a Rb+ efflux assay in the lymphocytes from nine patients with CRPS and 13 patients with LNP and compared with results from 14 healthy controls and nine medical controls. K+ channels were stimulated by KCl-induced membrane depolarization and characterized using the K+ channel blockers, margatoxin and charybdotoxin. Increasing the extracellular KCl concentration augmented the Rb+ efflux in all groups. The stimulated Rb+ efflux from lymphocytes of the medical and healthy controls was significantly attenuated by margatoxin (10 nM) alone and in combination with charybdotoxin (100 nM). In contrast, the Rb+ efflux from lymphocytes of patients with CRPS or LNP was not modified by either treatment. The Rb+ efflux from lymphocytes of healthy controls was significantly lower than that of the other groups. The K+ channel blockers increased the level of significance relative to the CRPS and LNP groups, but decreased the level of significance relative to the medical controls. These findings are consistent with an abnormal functioning of K+ channels in lymphocytes from patients with CRPS or LNP, which may be relevant to the pain in these conditions. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.''Green Studio'': Nature and the Arts in Therapy
02.Super-Spreading in Infectious Diseases
03.Lupus Renal Involvement: A Case-Based Atlas
04.New Research on Collective Behavior
05.The Evolving Human Primate: An Exploration through the Natural and Social Sciences
06.The Psychology of Effective Coaching and Management
07.Small Business in Brazil: Competitive Global Challenges
08.A-B-C: Analogues in Business Communication
09.Interprofessional Client-Centred Collaborative Practice: What Does it Look Like? How Can it be Achieved?
10.Economy, Politics and Governance Challenges for the 21st Century
11.Recent Advances on Using Virtual Reality Technologies for Rehabilitation
12.The Discourse of Digital Civic Engagement: Perspectives from the Developing World

Nova Science Publishers
© Copyright 2004 - 2016

Insensitivity of Lymphocytes of Patients with Neuropathic Pain Conditions to K+Channel Blockers (pp. 43-48)