Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Cancer » Neuro-Oncology and Cancer Targeted Therapy Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Advances in Pattern Recognition Research
$144.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Mechanisms of Immune Evasion Exhibited by Different Rat Glioma Cell Lines pp. 109-140
Tell A Friend
 
Tell someone you know about this product.
Mechanisms of Immune Evasion Exhibited by Different Rat Glioma Cell Lines pp. 109-140 $0.00
Authors:  (Martin R. Jadus, Lara Driggers, Neil Hoa, Jimmy T.H. Pham, Josephine Natividad, Christina Delgado, Edward W.B. Jeffes, Eric Giedzinski, Charles Limoli, Lisheng Ge, Pathology and Laboratory Medicine Service, Diagnostic and Molecular Medicine Health Care Group, VA Long Beach Healthcare System, Long Beach, California, and others)
Abstract:
Rat glioma cell lines could be considered the previous work horse of experimental glioma research. At least 9 established glioma cell lines exist and they have been used extensively to study many aspects of glioma biology and potential experimental therapeutics. These glioma cells have been defined as either being immunogenic or non-immunogenic, based upon empirical findings. The mechanisms of this immunogenicity/non-immunogenicity have not been fully elucidated. Traditionally, the major mechanisms by which murine tumors were viewed as being non-immunogenic was: by down-regulating the major histocompatibility complex (MHC) antigens, by lacking tumor specific antigens, or by making molecules that prevent the immune system from properly working. D74 glioma cells only showed low MHC class 1 (RT1-A) expression. Other non-immunogenic gliomas (F98, 36B10 and CNS-1) displayed equivalent levels of RT1-A, as their more immunogenic counterparts (RT2, BT4C, C6, 9L/T9). Human glioma cell lines possess numerous tumor-associated antigens. In contrast, rat tumor-associated antigens are relatively few. A plethora of immunosuppressive molecules are made by glioma cell lines. In this chapter we will examine why established rat glioma cell lines can grow in vivo, despite being considered ―immunogenic‖. The intrinsic properties (lack of MHC molecules, self-defense molecules, production of immunosuppressive cytokines/enzymes, counterattack strategies, growth rates and resistance to cell-mediated killing) of these cells may allow various aspects of rat glioma immunology to be explained and may allow investigators to focus on their favorite mechanism of immune evasion. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Peter Singerís Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

Mechanisms of Immune Evasion Exhibited by Different Rat Glioma Cell Lines pp. 109-140