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Advances in Medicine and Biology. Volume 127
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Brain and Spinal Cord Atrophy in Multiple Sclerosis
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Editors: Zivadinov, Robert (The Jacobs Neurological Institute, Buffalo, NY); Bakshi, Rohit (Brigham and Women’s Hospital, Harvard Medical School)
Book Description:
Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.

Table of Contents:
Acknowledgments

List Of Contributors

Abbreviations

Foreword
(Nancy Richert),
Uniformed Services University of Health Sciences, Bethesda);

Chapter 1. Central Nervous System Atrophy in Multiple Sclerosis: Introduction, pp. 1-4
(Robert Zivadinov et al., The Jacobs Neurological Institute);

Chapter 2. Central Nervous System Atrophy in Multiple Sclerosis: Mechanisms, pp. 5-13
(Alireza Minagar et al., Louisiana State University Health Sciences Center);

Chapter 3. Linear and Regional Measures of Brain Atrophy in Multiple Sclerosis, pp. 15-27
(Jack H. Simon, University of Colorado Health Sciences Center);

Chapter 4. Whole Brain Atrophy Measurement and Short-Term Brain Volume Changes, pp. 29-38
(Claudio Gasperini, Camillo-Forlanini Hospital, Multiple Sclerosis Center, Triste, Italy);

Chapter 5. The Measurement of Brain Atrophy in Multiple Sclerosis: Technical Aspects, pp.39-61
(Kathleen Garrison et al., University of California, San Francisco);

Chapter 6. Technical Aspects of Spinal Cord Atrophy Measurement, pp. 63-71
(Christopher R. Tench, University of Nottingham, UK and Cris S. Constantinescu, Queen’s Medical Center, Nottingham, UK);

Chapter 7. MRI Measures of Pathology and their Relationship to Central Nervous System Atrophy in Multiple Sclerosis, pp. 73-112
(Dominik S. Meier et al., Brigham & Women’s Hospital, Harvard Medical School);

Chapter 8. Neurologic Disability and Central Nervous System Atrophy in Multiple Sclerosis, pp. 113-136
(Robert Zivadinov, The Jacobs Neurological Institute and Rohit Bakshi, Brigham & Women’s Hospital, Harvard Medical School);

Chapter 9. Brain Atrophy, Cognitive Dysfunction and Emotional Disturbances in Multiple Sclerosis, pp. 137-166
(Ralph H. B. Benedict, Buffalo General Hospital and Dominic A. Carone, SUNY Buffalo School of Medicine);

Chapter 10. Relationship between Central Nervous System Atrophy and Genetic-Immunological Markers in Multiple Sclerosis, pp. 167-174
(Marino Zorzon, Cattinara Hospital, University of Trieste, Italy and Robert Zivadinov, The Jacobs Neurological Institute);

Chapter 11. Treatment Effects on MRI Measures of Central Nervous System Atrophy in Multiple Sclerosis, pp.175-190
(Marco Rovaris and Massimo Filippi, Scientific Institute and University H San Raffaele, Italy);

Index.

   Binding: Hardcover
   Pub. Date: 2004
   ISBN: 1-59454-160-4
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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