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Neocortical Modularity and the Cell Minicolumn
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Editors: Manuel F. Casanova (University of Louisville) (Editor)
Book Description:
Our everyday view of the world may not necessarily be the most comprehensive one. In this regard neuropathologists should temper opinions based on a limited representation of reality. Microscopy freezes in time a two-dimensional representation of a minute histological process. One must acquire knowledge of the physiology of the lesion before reaching a multidimensional diagnosis. In the case of mental disorders, the modular organization of the cortex may offer some clues to underlying etiology. It is tissue, rather than individual cells, that provides for the phenomena of perceptual binding and gamma frequencies. It is the continuous reentry of excitation into neuronal networks that provides for selective attention. The basis for language and its semantic content resides in the conjoint activation of topographically diverse brain regions.
This book is designed to focus on the lowest hierarchical element within the modular organization of the brain: the cell minicolumn. The minicolumn is a self-contained ecosystem of neurons and their connections that repeats itself throughout the extent of the neocortex. Although a few neuroanatomists at the turn of the century called attention to the vertical arrangement of the cortex, Vernon Mountcastle provided physiological proof in the 1950’s for its existence and its role in perception.

Table of Contents:

Introduction (Manuel F. Casanova, University of Louisville)

Chapter 1. A Life that Transformed the Neurosciences (Vernon B. Mountcastle, University of Louisville) pp. 1-13

Chapter 2. Scientific Achievements (Vernon B. Mountcastle and Juan Trippe II, University of Louisville) pp. 15-32

Chapter 3. An Apologia for a Paradigm Shift in the Neurosciences (Manuel F. Casanova, University of Louisville) pp. 33-55

Chapter 4. Reflections on the Structure of the Cortical Minicolumn (Javier Defelipe, Instituto Cajal (CSIC), Madrid, Spain) pp. 57-92

Chapter 5. The Cell Column in Comparative Anatomy (Daniel Buxhoeveden, Medical College of Georgia) pp. 93-116

Chapter 6. Encephalization, Minicolumns, and Hominid Evolution (Daniel Buxhoeveden, Medical College of Georgia) pp. 117-136

Chapter 7. The Generation and Migration of Cortical Interneurons (John G. Parnavelas, University College London, UK) pp. 137-144

Chapter 8. Minicolumnar Patterns in the Global Cortical Response to Sensory Stimulation (Mark Tommerdahl et al., University of North Carolina School of Medicine) pp. 145-160

Chapter 9. Minicolumnar Morphometry: Computerized Image Analysis (Manuel F. Casanova and Andrew E. Switala, University of Louisville) pp. 161-179

Chapter 10. The Verticality Index: A Quantitative Approach to the Analysis of the Columnar Arrangement of Neurons in the Primate Neocortex (Axel Schleicher and Karl Zilles, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany) pp. 181-185

Chapter 11. Mountcastle Principle of Columnar Cortex as a Basis for the Theory of Higher Brain Function: Clinical Relevance (Gordon L. Shaw and Mark Bodner, M.I.N.D. Institute) pp. 187-203


   Binding: Hardcover
   Pub. Date: 2005
   ISBN: 1-59454-301-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Neocortical Modularity and the Cell Minicolumn