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Protein-Protein Interactions
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Editors: Pandjassarame Kangueane (Bioinformatics & Biotechnology, AIMST, Malaysia)
Book Description:
This book describes the fundamental physical, chemical, molecular and biological aspects of proteins binding to one another in cellular biology. PPI is a common phenomenon in cell and molecular biology events. The networks of PPI describe cellular function in both unicellular and multi-cellular organisms. Homo complexes (dimers of identical monomers) or hetero complexes (dimers of non-identical monomers) are involved in PPI. These complexes are common in catalysis, regulation and structural assembly. However, the molecular principles of protein interactions are difficult to understand due to the geometrical and chemical characteristics of proteins. The challenge today is to identify interaction partners and sites from sequence and/or structures. This book describes the principles (physics and chemistry) of PPI and protein interfaces to develop models for PPI predictions. (Imprint: Nova Biomedical)

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Table of Contents:

Author List

1. Protein – protein complexes
(Gopichandran Sowmya, Ayyappan Vaishnavi, Anupama Jigisha, Pandjassarame Kangueane) pp.1-74

2. Prediction of highly-connected hubs in protein interaction networks by QSAR and biological data descriptors (Michael Hsing, Kendall Byler, Artem Cherkasov)pp.75-102

3. Protein oligomerization and gene fusion in cancer
(Ju Lin Tan, Gopichandran Sowmya, Pandjassarame Kangueane)pp.103-116

4. Immunological protein-protein interactions: a critical reflection
(Darren Flower)pp.117-140

5. Databases and methods for protein-protein/peptide interactions
(Venkatarajan Subramanian Mathura, Sasikumar Reddy, Sathish Kumar Ramakrishnan, Sangari Ashok kumar, Gopichandran Sowmya)pp.141-154

6. Interface roughness in heteromeric obligate and non-obligate protein-protein complexes
(Indrani Bera, Somak Ray)pp.155-166

7. NASCENT: An automatic protein interaction network generation tool for non-model organisms
(Daniel Banky, Rafael Ordog, Vince Grolmusz)pp.167-172

8. PINAT1.0: Protein interaction network analysis tool
(Sandeep K. Kushwaha, Madhvi Shakya)pp.173-178

9. Folding and binding of homodimers
(Gopichandran Sowmya, Ayyappan Vaishnavi, Abishek Suresh, Velmurugan Karthikraja, Pandjassarame Kangueane)pp.179-210

10. Molecular dynamics in PPI (unfused) and fused homologous proteins
(Yu Yiting, Meena Kishore Sakharkar, Pandjassarame Kangueane)pp.211-224

11. Interface hot spots in protein complexes
(Lei Li, Ayyappan Vaishnavi, Gopichandran Sowmya, Pandjassarame Kangueane)pp.225-250

12. Protein-protein interfaces in cholera toxin complex
(Gunasagaran Shamini, Manickam Ravichandran, Pandjassarame Kangueane)pp.251-272

13. Taq DNA polymerase interactions with DNA and Fab
(Nalayini Subramaniam, Pattabiraman Lalitha, Pandjassarame Kangueane)pp.273-292

14. Evolutionary dynamics at protein-protein interfaces of legume lectins
(Lakshmipuram Seshadri Swapna, Bernard Offmann, Narayanaswamy Srinivasan)pp.293-310

15. Protein-protein and protein-lipid interactions in immune cell signalling
(Amudhala Karthik, Joseph Antoniraj Jude Aarthi, Deng Yiru, Ali M Darendeliler, Peter Natesan Pushparaj) pp.311-326

Contributor's List pp.325-326

Index pp.327-336

      Biochemistry Research Trends
   Binding: Hardcover
   Pub. Date: 2011 - 2nd quarter
   Pages: 7 x 10 336.pp
   ISBN: 978-1-61761-548-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Protein-Protein Interactions