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Genome and Proteome in Oncology
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Editors: Stathopoulou, Fotini Tzortzatou (University of Athens and “Aghia Sofia” Children’s Hospital, Goudi)
Book Description:
The nature of cancer disease, its probable causes, and the molecular and cellular mechanisms through which malignant tumors develop, have only recently begun to be understood in any appreciable detail. Cancer is fundamentally a disease of the genome, arising from dynamic changes occurring within DNA during the lifetime of the cell e.g. deletions, amplifications, point mutations, translocations, that can occur in any cell and that may interact in a variety of cellular pathways. The imbalance in the interplay between genetic and environmental factors can initiate malignancy. The determination of the human genome sequence is acclaimed as one of the great achievements made possible by the rapid progress in the available molecular biology tools achieved during the last few years. The sequence of the human genome promises to unveil invaluable information useful for the development of novel approaches in the diagnosis and treatment of cancer disease.
This book includes part of the work of international experts on the most up-to-date developments of various aspects of research on genome and proteome in oncology. The scientists suggest that the genetic key to human complexity lies not in the number of genes but in how gene parts are used to build different products in a process of the mRNA transcript called alternative splicing.

Table of Contents:
Chapter Availability

Individual chapters are available for $25 each by sending an email to novascience@earthlink.net. Nova will provide the chapter for your easy downloading or send it as an email attachment if you prefer.

Preface; Chapter 1. DNA and its Relationship to Cancer (Spyros Vlachopoulos and Vassilis Zoumpourlis, Institute of Biological Research and Biotechnology, Greece); Chapter 2. Global Amplification of Sense RNA: A Novel Method to Replicate and Archive RNA for Cancer Biomarker Discovery and Validation (Mangalathu S. Rajeevan et al., National Center for Infectious Diseases, Centers for Disease Control and Prevention); Chapter 3. Genome Reviews and Proteome Analysis (Nadeem Faruque et al., European Bioinformatics Institute); Chapter 4. Genomics and Proteomics in the Early Detection and Prevention of Cancer (Fiona Simpkins et al., National Cancer Institute, Bethesda); Chapter 5. Proteomic Analyses in Oncology (Alasdair C Stamps et al., Celltech R&D, England); Chapter 6. SELDI-TOF Profiling for Clinical Diagnostic Assay Development (Lisa H. Cazares et al., Eastern Virginia Medical School); Chapter 7. Proteomic Techniques for Individualized Cancer Therapy (Lorri-Anne F. Burke et al., National Cancer Institute, Bethesda); Chapter 8. Proteomics in Breast Cancer (Serhiy Souchelnytskyi, Ludwig Institute for Cancer Research, Sweden); Chapter 9. Application of Proteomics to Prostate Cancer Research (Hidetoshi Kuruma et al., Kitasato University School of Medicine, Japan); Chapter 10. The Role of Proteomics Applications in Brain Tumor Biomarker Discovery (A. Umar and T. M. Luider); Chapter 11. Tumor-associated Proteins in Chemically Induced Rat Hepatomas and their Analogous Proteins in Human Hepatocellular Carcinomas (Evelyn Zeindl-Eberhart et al., Institute of Pathology, University of Munich, Germany); Chapter 12. Gene Expression Profiling and its Application for Characterization of Mechanism(s) of Action of Anti-cancer Drugs, Molecular Classification and Prognostication in Hematologic Malignancies: Focus on Plasma Cell Dyscrasias (Constantine S. Mitsiades and Nicholas Mitsiades, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School); Chapter 13. Proteomic Profiling Studies for Delineation of Mechanism(s) of Action of Anti-cancer Drugs, Molecular Classification and Prognostication of Human Malignancies: Focus on Multiple Myeloma and other Plasma Cell Dyscrasias (Constantine S. Mitsiades and Nicholas Mitsiades, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School); Chapter 14. Biomarkers in Cancer Detection and Risk Assesment (Mukesh Verma and Sudhir Srivastava, National Cancer Institute, Bethesda); Chapter 15. Gene Expression Profile of Childhood Acute Lymphoblastic Leukemia During Chemotherapy by cDNA Microarrays (George I. Lambrou et al., University of Athens); Chapter 16. Epstein-Barr virus Infection and Viral Gene Expression in Pediatric Non-Hodgkin Lymphomas (Matthias A. Karajannis et al., Memorial Sloan-Kettering Cancer Center); Chapter 17. Genome and Proteome in Neuroblastoma (Kalliopi Gana et al., University of Athens); Index.

   Binding: Hardcover
   Pub. Date: 2005
   ISBN: 1-59454-285-6
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
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Genome and Proteome in Oncology