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Field Cancerization: Basic Science and Clinical Applications $295.00
Editors: Gabriel D. Dakubo (Mito-Onc Consultancy, Ontario, Canada)
Book Description:
The presence of multiple cancers in one patient has excited the interest of many investigators, and considerable literature has accumulated on this subject. The scientific concepts and clinical importance of field cancerization are the subject matter of this book. This book is a compendium of importance to oncologists and cancer researchers and caregivers. Existent knowledge on cancer biology and therapy has been vastly expanded by this concept of cancer evolution. Expanding “super-competitors”, multistep carcinogenesis, and stem cell theories are some novel mechanistic models of carcinogenesis discussed in this book. Extensively covered in this book as well, are the cellular and molecular changes representative of field cancerization in several cancers, including hematologic and pediatric cancers.


(Imprint: Nova Biomedical)

Table of Contents:
Contributors

Preface

Dedication

Part I – Mechanisms of Field Cancerization

Chapter 1 - Expanding Supercompetitors as Mechanism of Field Cancerization
(Eduardo Moreno, Christa Rhiner and Davide Soldini)

Chapter 2 - The Multistep Field Cancerization Theory of Carcinogenesis
(Sabrina L. Spencer and Miguel H. Bronchud)

Chapter 3 - Development of Tumor Stem Cells: Implication in Field Cancerization
(Jian-Xin Gao)

Part II – Epedemiological Aspects of Field Cancerization

Chapter 4 - Epidemiology of Synchronous and Metachronous Type Multiple Primary Neoplasms
(Sevil Kılçıksız and Beste M. Atasoy)

Chapter 5 - Field Cancerization in Derivatives of the Embryonic Foregut: An Observation Based on Epidemiological Patterns
(Donald E. Henson, Jorge Albores-Saavedra, Arnold M. Schwartz and Kristen Batich)

Part III – Clinical and Molecular Aspects of Field Cancerization in Specific Tissues

Chapter 6 - Field Cancerization and Oral Leukoplakia
(Liviu feller and Johan Lemmer)

Chapter 7 - Field Cancerization in Head and Neck Squamous Cell Carcinoma with Focus on Second Primary Tumors
(Rostam D. Farhadieh)

Chapter 8 - Field Cancerization in Esophageal Epithelia Demonstrated by Telomere Shortening and Chromosomal Instability
(Makoto Kammori)

Chapter 9 - Field Cancerization in Mammary Tissues
(Marco Bisoffi, Christopher M. Heaphy and Jeffrey K. Griffith)

Chapter 10 - Field Cancerization in Gastric Cancer
(Toshikazu Ushijima and Takeichi Yoshida)

Chapter 11 - Field Cancerization in Colorectal Cancer
(Jun Kato)

Chapter 12 - Epigenetic Changes in Hepatic Tissues: Evidence of Field Cancerization
(Yutaka Kondo)

Chapter 13 - Molecular Genetic Alterations in Preneoplastic And Neoplastic Lesions Of the Gallbladder
(Juan C. Roa and Jonathan Castillo)

Chapter 14 - Field Cancerization in Intraductal Papillary Mucinous Neoplasia of the Pancreas
(Satoshi Tanno and Takeshi Obara)

Chapter 15 - Field Cancerization iIn Urothelial Carcinomas of the Upper Urinary Tract
(Maxmillan Burger and Arndt Hartmann)

Chapter 16 - Clonality of Multifocal Urothelial Cancer and Field Cancerization
(Tomonori Habuchi and Tadao Kakizoe)

Chapter 17 - Evidence of Skin Field Cancerization
(J. Andrew Carlson, Michael Murphy, Andrzej Slominski, and Vincent L. Wilson)

Chapter 18 - Management of Field Cancerization: The Case of Actinic Keratosis
(Kave Shams and Girish Gupta)

Chapter 19 - Field Cancerization in Endometrial Carcinoma
(Tracy Tipton, Jinping Li, Juan Ren, Russell Broaddus, Yi L. Hwa, Donald Gallup and Shi-Wen Jiang)

Chapter 20 - Field Cancerization in Vulvar, Vaginal and Cervical Epithelia
(Ann H. Klopp and Anuja Jhingran)

Chapter 21 - Molecular Signatures in Ovarian Cancer
(Celestine S. Tung and Kwong K. Wong)

Chapter 22 - Epigenetic Changes in Prostatic Tissues: Evidence of Field Cancerization
(Devendar Katkoori, Rakesh Singal and Murugesan Manoharan)

Chapter 23 - Epigenetic Field Changes in Pediatric Cancers
(Kornelius Kerl and Michael C. Frühwald)

Chapter 24 - Epigenetics in Hematological Malignancies
(Ulrich Lehmann)

Part IV – Biomarker Development and Therapy Targeting of Epigenetics

Chapter 25 - Molecular Signatures as Cancer Biomarkers: Methodologic Issues in Discovery, Validation, Qualification, and Standardization
(Laura B. Pritzker and Kenneth P.H. Pritzker)

Chapter 26 - Chemoprevention Targeting Epigenetic Changes in Cancer
(Fiona S. Poke and Adele F. Holloway)

Index

   Series:
      Cancer Etiology, Diagnosis and Treatments
   Binding: ebook
   Pub. Date: 2010 4th quarter
   Pages: 7 x 10
   ISBN: 978-1-61761-386-9
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Field Cancerization: Basic Science and Clinical Applications