Hyaluronan Stimulates Mobilization of Mature Hematopoietic Cells but Not Hematopoietic Progenitors pp. 191-202
Authors: Ingrid Schraufstatter, Naira Serobyan, Richard DiScipio, Natalia Feofanova, Irina Orlovskaya and Sophia Khaldoyanidi
Abstract: Mobilization of hematopoietic stem/progenitor cells (HSPCs) is currently a routine clinical procedure that enables the harvesting of HSPCs from peripheral blood and their further use for transplantation and tissue regeneration. Despite of the recent progress in HSPC mobilization strategies, it is generally agreed that further improvement of mobilization protocols is needed to achieve a better quantity and quality of harvested HSPC in a higher percentage of donors (Pelus 2008). The protocols for HSPC mobilization are based on understanding the molecular mechanisms that regulate homing of these cells into the bone marrow and their retention within the niche. In particular, several chemokines, cytokines, growth factors, their receptors, adhesion molecules as well as hormones and proteases have been identified as contributors to the complex network that regulates migration of HSPCs (Lapidot and Petit 2002; Cottler-Fox, Lapidot et al. 2003; Levesque and Winkler 2008; Pelus 2008; Schulz, von Andrian et al. 2009). Apparently, agents used for HSPC mobilization interrupt these pathways and enable HSPC to detach from the niche, migrate through the matrix, egress from the bone marrow and enter the circulation.