Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Medical General » Chronic Fatigue Syndrome: Symptoms, Causes and Prevention Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Use of Cyclodextrin Polymers in Separation of Organic Species
$59.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The NO/ONOO-Vicious Cycle Mechanism as the Cause of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis pp. 27-56
Tell A Friend
 
Tell someone you know about this product.
The NO/ONOO-Vicious Cycle Mechanism as the Cause of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis pp. 27-56 $0.00
Authors:  Martin L. Pall, Washington State University and Research Director, The Tenth Paradigm Research Group
Abstract:
Cases of chronic fatigue syndrome/mylagic encephalomyelitis (CFS) are reported to be initiated by nine different short-term stressors, each of which increases levels of nitric oxide in the body. Elevated nitric oxide, acting through its oxidant product, peroxynitrite, initiates a local biochemical vicious cycle, the NO/ONOO- cycle, which is proposed to be the cause of CFS and related diseases. Evidence supporting this cycle mechanism in CFS comes from each of the following types of evidence: Case initiation by such stressors, the extensive evidence supporting the existence of individual cycle mechanisms, evidence showing that various cycle elements are elevated in CFS cases, evidence for a basically local mechanism in CFS and related diseases, evidence from CFS animal models, genetic evidence from genetic polymorphism studies and evidence from clinical trials of agents predicted to down-regulate the NO/ONOO-cycle. Each of the five principles underlying the NO/ONOO- cycle mechanism is supported by one or more of the above described types of evidence. The cycle involves oxidative stress, excessive nitric oxide synthase (NOS) activity, mitochondrial dysfunction, inflammatory biochemistry, excitotoxicity including excessive NMDA activity and tetrahydrobiopterin depletion. There is evidence, ranging from extensive to modest, supporting roles for each of these in CFS. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Isoprostanes and Neuroprostanes: Production and Role in Different Pathologies
02.Women and War: Opening Pandora’s Box - Intimate Relationships in the Shadow of Traumatic Experiences
03.Deciphering Organic Foods: A Comprehensive Guide to Organic Food Production, Consumption, and Promotion
04.Developing Critical Thinking: A Multi-Dimensional Approach in the Context of South Africa
05.Photonic Crystals: Characteristics, Performance and Applications
06.Embodied Cognition: Theories and Applications in Education Science
07.Slovenia: Social, Economic and Environmental Issues
08.Chemoradiotherapy: Concurrent Uses, Efficacy and Impact on Prognosis
09.Autism Patents and Beyond
10.Advances in Carcinogenesis Research
11.Digital Stories and Their Integration in Early Childhood and Primary Education: Teaching Scenarios and Practical Ideas
12.Azobenzene: Aspects, Applications and Research

Nova Science Publishers
© Copyright 2004 - 2017

The NO/ONOO-Vicious Cycle Mechanism as the Cause of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis pp. 27-56