BENEFICIAL EFFECTS OF SOLUBLE FIBER (PLANTAGO OVATA HUSK) ON PLASMA TRIGLYCERIDES AND APOLIPOPROTEIN B TO APOLIPOPROTEIN A-I RATIO IN MEN IN CARDIOVASCULAR DISEASE SECONDARY PREVENTION, pp. 211-220
Authors: Rosa Solà, Adriana Alvaro, Rosa M. Valls, Joan-Carles Vallvé, Anna Anguera, Unitat de Recerca en Lípids i Arteriosclerosi, Ciberdem, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain, and others
Abstract: Background: New dietary strategies to reduce cardiovascular disease (CVD) risk include, as part of secondary prevention, the addition of fiber to the diet. Objective: To study the effect of treatment with soluble-fiber derived from Plantago ovata (Po) husk on lipids, in 28 men with CVD and plasma low density lipoprotein (LDL)-cholesterol concentration ≤3.35 mmol/L (≤130 mg/dL). A low-saturated-fat diet supplemented with 10.5 g/d Po husk was consumed for 8 weeks, under controlled conditions. Results: Following Po husk treatment, plasma apolipoprotein (apo) A-I increased 4.3% (P<0.01 and plasma triglycerides decreased 6.7% (P<0.02), the apo B 100/ apo A-I ratio decreased 4.7% (P<0.02) from (mean ±SD) 0.77±0.10 to 0.73±0.19. Conclusion: In secondary prevention of CVD, Po husk treatment induces a reduction in the apoB/apoA-I ratio, a measure that is identified as a strong new risk factor for CVD and which is a target for lipid-lowering therapy; the lower the apoB/apoA-I ratio, the lower is the risk. No effect on plasma LDL cholesterol was observed. Possible Po husk modes-of-action will be proposed.
Open Access item.
Click below PDF icon for free download.
This is an Open Access item. Click above PDF icon for free download.