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NotificationsNotify me of updates to BENEFICIAL EFFECTS OF SOLUBLE FIBER (PLANTAGO OVATA HUSK) ON PLASMA TRIGLYCERIDES AND APOLIPOPROTEIN B TO APOLIPOPROTEIN A-I RATIO IN MEN IN CARDIOVASCULAR DISEASE SECONDARY PREVENTION, pp. 211-220
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BENEFICIAL EFFECTS OF SOLUBLE FIBER (PLANTAGO OVATA HUSK) ON PLASMA TRIGLYCERIDES AND APOLIPOPROTEIN B TO APOLIPOPROTEIN A-I RATIO IN MEN IN CARDIOVASCULAR DISEASE SECONDARY PREVENTION, pp. 211-220 $0.00
Authors:  Rosa Solà, Adriana Alvaro, Rosa M. Valls, Joan-Carles Vallvé, Anna Anguera, Unitat de Recerca en Lípids i Arteriosclerosi, Ciberdem, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain, and others
Abstract:
Background: New dietary strategies to reduce cardiovascular disease
(CVD) risk include, as part of secondary prevention, the addition of fiber to
the diet.
Objective: To study the effect of treatment with soluble-fiber derived
from Plantago ovata (Po) husk on lipids, in 28 men with CVD and plasma
low density lipoprotein (LDL)-cholesterol concentration ≤3.35 mmol/L
(≤130 mg/dL). A low-saturated-fat diet supplemented with 10.5 g/d Po husk
was consumed for 8 weeks, under controlled conditions.
Results: Following Po husk treatment, plasma apolipoprotein (apo) A-I
increased 4.3% (P<0.01 and plasma triglycerides decreased 6.7% (P<0.02),
the apo B 100/ apo A-I ratio decreased 4.7% (P<0.02) from (mean ±SD)
0.77±0.10 to 0.73±0.19.
Conclusion: In secondary prevention of CVD, Po husk treatment
induces a reduction in the apoB/apoA-I ratio, a measure that is identified as a
strong new risk factor for CVD and which is a target for lipid-lowering
therapy; the lower the apoB/apoA-I ratio, the lower is the risk. No effect on
plasma LDL cholesterol was observed. Possible Po husk modes-of-action
will be proposed. 


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BENEFICIAL EFFECTS OF SOLUBLE FIBER (PLANTAGO OVATA HUSK) ON PLASMA TRIGLYCERIDES AND APOLIPOPROTEIN B TO APOLIPOPROTEIN A-I RATIO IN MEN IN CARDIOVASCULAR DISEASE SECONDARY PREVENTION, pp. 211-220