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Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Surface Engineering, Cytotoxicity and Biomedical Applications
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Authors: Morteza Mahmoudi (Sharif University of Technology, Tehran, Iran), Pieter Stroeve (The University of California at Davis, USA), Abbas S. Milani (The University of British Columbia at Okanagan, Canada), Ali S. Arbab (Henry Ford Hospital, Detroit, MI, USA) 
Book Description:
In recent years, the fabrication of nanoparticles and exploration of their properties have attracted the attention of physicists, chemists, biologists and engineers. Interest in nanoparticles arise from the fact that the mechanical, chemical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. There are numerous areas where nanoparticulate systems are of scientific and technological interest. This new book reviews research on the various components of superparamagnetic iron oxide nanoparticles.

Imprint: Nova Science


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Table of Contents:
1. Introductory to the Book pp.1-10

1.1. Semiconducting Nanoparticles

1.2. Iron Oxide Nanoparticles

1.3. Biomineralization

1.4. Types of Magnetic Iron Oxides

1.5. Synthesis of Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Chemical Coprecipitation

1.6. Design of Experiments (DOE) for Synthesis of SPIONs

2. Synthesis of SPIONs,pp. 11-49

2.1. Nucleation of Nanoparticles

2.2. Synthesis Methods

2.2.1. Chemical Methods

2.2.1.1. Co-Precipitation

2.2.1.2. Microemulsions

2.2.1.3. Hydrothermal

2.2.1.4. Thermal Decomposition

2.2.1.5. Sol-gel

2.2.1.6. Polyol

2.2.1.7. Sonochemical

2.2.1.8. Electrochemical Deposition

2.2.2. Physical Methods

2.2.2.1. Flow Injection

2.2.2.2. Aerosol/Vapor

2.2.2.3. Pulsed Laser Ablation

2.2.2.4. Laser Induced Pyrolysis

2.2.2.5. Powder Ball Milling

2.2.3. Biological/ Bio-Mineralization

2.3. Thermal Decomposition

2.4. Microemulsion

2.5. Hydrothermal Synthesis

2.6. Other Methods

3. Application of Statistical Techniques pp.51-70

3.1. The Two Sample t-Test

3.2. Hypothesis Testing for Outlier Detection -- Grubbs' Test

3.3. Design of Experiments

3.4. Checking Model Assumptions: Effect of Potentially Outlying Observations

4. Coatings of SPIONs pp.71-124

4.1. Colloidal Stability of SPIONs

4.2. Polymeric Coating

4.2.1. Polyethylene Glycol

4.2.2. Polyethylene Glycol fumarate

4.2.3. Polyvinyl Alcohol

4.2.4. Polyacrylic Acid

4.2.5. Poly(N-isopropylacrylamide)

4.2.6. Dextran

4.2.7. Poly(D,L-lactide)

4.2.8. Poly(D,L-lactide-co-glycolide)

4.2.9. Alginate

4.2.10. Chitosan and Polyethylenimine

4.3. Non-Polymeric Coating

4.3.1. Gold

4.3.2. Silica

4.4. Functionalization of SPIONs

5. Cytotoxicity of SPION pp.125-162

5.1. Cytotoxicity versus Biocompatibility

5.2. In vitro Toxicity Assays

5.2.1. Metabolic Activity

5.2.1.1. MTT Assay

5.2.1.2. XTT Assay

5.2.1.3. MTS Assay

5.2.1.4. Redox Assay

5.2.1.5. Adenosine Triphosphate Assay

5.2.1.6. Cytochrome C Assay

5.2.1.7. Nitroblue Tetrazolium (NBT) Assay

5.2.1.8. WST Assay

5.2.2. Membrane Integrity

5.2.2.1. LDH Assay

5.2.2.2. Live/Dead Assay

5.2.2.3. Dye Assays

5.2.2.3.1. NR Assay

5.2.2.3.2. Trypan Blue Exclusion Assay

5.2.2.3.3. Erythrosine B Assay

5.2.2.3.4. Propidium Iodide Assay

5.2.2.3.5. Bromodeoxyuridine (BrdU) Assay

5.2.2.3.6. DNA Hoechst Assay

5.2.3. Cell Proliferation Assay

5.2.3.1. Cell Cycle Assay

5.2.3.2. [3H] Thymidine Incorporation Assay

5.2.4. Apoptosis Detection

5.2.4.1. Flow Cytometry

5.2.4.2. Comet Assay

5.3. In vivo Toxicity

5.4. Pharmacokinetics and Biodistribution

6. Application of SPIONs pp.163-212

6.1. SPIONs as Magnetic Resonance Imaging Contrast Agent

6.2. SPIONs for Magnetic Labeling of Cells

6.3. SPIONs and Magnetically Labeled Cells for Multimodal Regimens

6.4. SPIONs as Drug Delivery Vehicles

6.5. SPIONs for Hyperthermia Treatment

6.6. SPIONs for Enhanced Transfection of DNA (Magnetofection)

6.7. SPIONs for Cell/Protein Separation

6.8. SPIONs as Catalyst

6.9. SPIONs for Tissue Repair

Index pp.213-225

   Series:
      Nanotechnology Science and Technology
   Binding: Hardcover
   Pub. Date: 2011
   Pages: 7 x 10 225 pp.
   ISBN: 978-1-61668-964-3
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Surface Engineering, Cytotoxicity and Biomedical Applications