Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genetics » Advances in Genetics Research, Volume 1 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Central Asia: Perspectives and Present Challenges
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Immunogenetics of Allergic Sensitization: Selection of the IgE Repertoire
Tell A Friend
Tell someone you know about this product.
The Immunogenetics of Allergic Sensitization: Selection of the IgE Repertoire $0.00
Authors:  Michael Zemlin, Tobias Rogosch, Sebastian Kerzel, University Children's Hospital, Marburg, Germany, and others
The central effector molecule of allergic immune responses is immunoglobulin E (IgE). IgE bound to the surface of mast cells generates the interface between allergens and the immune system on the effector side of the allergic immune response. The cross-linkage of two adjacent membrane bound IgE molecules is the most important trigger for mast cell degranulation, leading to the consecutive release of proinflammatory mediators that orchestrate the allergic inflammation.
The functional properties of the interface between the allergen and the immune system are an interesting target for understanding the mechanisms of allergic sensitization and the allergic immune response. The core of this interface is the classical antigen binding site, which is the part of the immunoglobulin that determines the specificity and affinity of the antibody. The almost infinite diversity of the antibody is generated by the processes of combinatorial diversity, junctional diversity, and somatic point mutations. Thus, during allergic sensitization, the antibody repertoire is focused by selection processes, leading to expansion of specific B cell clones.
Studies of the IgE repertoire have started only recently due to the availability of novel RT-PCR based techniques. Initial studies suggested that the IgE repertoire may be differently regulated than the repertoires of other isotypes. Particularly in allergic patients, the repertoire of IgE heavy chain transcripts displayed remarkable characteristics in terms of variable gene usage, length of the third hypervariable loop of the classical antigen binding site (CDR-H3), and somatic mutation rate. These unusual properties may have profound impact on the specificity, affinity, and polyreactivity of the expressed IgE repertoire. 

Available Options:

  Open Access item.
  Click below PDF icon for free download.


This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.The New Science of Curiosity
03.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
04.Chronic Disease and Disability: The Pediatric Lung
05.Fruit and Vegetable Consumption and Health: New Research
06.Future Perspectives on Nigella sativa: Characterization and Pharmacological Properties
07.Wine and Winemaking: The Value and Efficiency
08.Impacts and Challenges in Oil Palm Cultivation and Downstream Applications of Biomass
09.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2
10.The Life and Times of the World's Most Famous Mathematicians
11.Innovation Processes in the Social Space of the Organization
12.High-Strength Steels: New Trends in Production and Applications

Nova Science Publishers
© Copyright 2004 - 2018

The Immunogenetics of Allergic Sensitization: Selection of the IgE Repertoire