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05.A System Architecture Approach to the Brain: From Neurons to Consciousness
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Focus on Alzheimer’s Disease Research
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Editors: Welsh, Eileen M.
Book Description:
Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory problems and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years.
Current research is aimed at understanding why AD occurs and who is at greatest risk of developing it, improving the accuracy of diagnosis and the ability to identify those at risk, discovering, developing, and testing new treatments, and discovering treatments for behavioral problems in patients with AD. This new book gathers state-of-the-art research from leading scientists throughout the world which offers important information on understanding the underlying causes and discovering the most effective treatments for Alzheimer's Disease.

Table of Contents:
Preface; Alzheimer’s Dementia: a Metabolic Perspective (Miao-Kun Sun and Daniel L. Alkon, Blanchette Rockefeller Neurosciences Institute); Dementia, Estrogen, and Diet: A Possible Role of Phytoestrogens (Isoflavones) in Alzheimer’s Disease? (Edwin D Lephart and Dawson W. Hedges, Brigham Young University); Clinical Perspectives for the Use of Melatonin in Alzheimer’s Disease (Daniel P. Cardinali, Analía M. Furio, Luis I. Brusco and Cynthia Liberczuk, University of Buenos Aires, Argentina); Cytokines in Alzheimer’s Disease: Views Through a Kaleidoscope (Ning Quan, Ohio State University); Dysfunction and Activation of the Lysosomal System: Implications for and against Alzheimer’s Disease (Ben A. Bahr, University of Connecticut); Lipid Raft as a Nidus for the Conformational Alternation and the Aggregation of Alzheimer's Amyloid βh-Protein (Katsumi Matsuzaki, Kyoto University, Japan); The Presenilins and their Role in Amyloid-β Generation (Giuseppe Verdile, University of Western Australia; Samuel E. Gandy, Thomas Jefferson University; Paul Fraser, Centre for Research in Neurodegenerative Diseases and Departments of Medical Biophysics and Medicine (Neurology), University of Toronto; Craig S. Atwood, Case Western Reserve University; Ralph N. Martins, University of Western Australia); The Role of Vascular Risk, Beta-Amyloid Metabolism and Neuroinflammation in the Genetics of Late-onset Alzheimer’s Disease (Francesco Panza, Alessia D’Introno, Anna M. Colacicco, Cristiano Capurso, Anna M. Basile, Antonio Capurso, and Vincenzo Solfrizzi, University of Bari, Italy); Ethics Research in Dementia: The Way Forward? (Julian C. Hughes, Newcastle General Hospital, England); Diagnostic Criteria for Dementia, Mild Cognitive Impairment and Alzheimer Disease (A. Robles, Hospital Clínico Universitario, Santiago de Compostela; T. Del Ser, Hospital Severo Ochoa; J. Alom, Hospital General Universitario, Elche; J. Peña-Casanova, Instituto Municipal de Asistencia Sanitaria, Hospital del Mar, Barcelona, Spain); When Memory Fails: Assessment and Care of Persons with Alzheimer’s Disease (Fay L. Bower, Holy Names College and Cyndi S. McCullough, HDR, INC); Patients with Dementia and their Caregivers in Taiwan (Jong-Ling Fuh, Veterans General Hospital-Taipei, Taiwan); Index.

   Binding: Hardcover
   Pub. Date: 2003
   ISBN: 1-59033-788-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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