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01.Eosinophils: Structure, Biological Properties and Role in Disease
02.Regulatory T Cells
03.Immunosuppression: New Research
04.Lupus Renal Involvement: A Case-Based Atlas
05.Mannose-Binding Lectin in the Innate Immune System
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Immunosuppression: New Research $110.00
Editors: Charles B. Taylor
Book Description:
Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. Deliberately induced immunosuppression is generally done to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as rheumatoid arthritis or Crohn's disease. This is typically done using drugs, but may involve surgery (splenectomy), plasmapharesis, or radiation.

A person who is undergoing immunosuppression, or whose immune system is weak for other reasons (for example, chemotherapy and HIV patients) is said to be immunocompromised. When an organ is transplanted, the immune system of the recipient will most likely recognize it as foreign tissue and attack it. The destruction of the organ will, if untreated, end in the death of the recipient.

In the past, radiation therapy was used to decrease the strength of the immune system, but now immunosuppressant drugs are used to inhibit the reaction of the immune system. The downside is that with such a deactivated immune system, the body is very vulnerable to opportunistic infections, even those usually considered harmless. Also, prolonged use of immunosuppressants increases the risk of cancer.

This new book presents the latest research in the field.

Table of Contents:

Is there a future for costimulation blockade as a regulatory t- cell inducing therapy?
(Krista G. Haanstra, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Bert A. Hart, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Frans H.J Claas,Leiden University, Leiden, Margreet Jonker, Biomedical Primate Research Centre, Rijswijk, The Netherlands)

Strategies for T cell Depletion to Prevent Graft versus Host Disease
(Liang- Piu Koh, Duke University,National University Hospital, Singapore, David A. Rizzieri, Duke University Medical Center)

Leucocyte intracellular cytokines in lung transplant patients- a more physiological indicator of immunosuppression than plasma drug levels
(Greg Hodge,Sandra Hodge, Paul Reynolds, Daniel Chambers, Mark Holmes)

Indications and management of m-TOR inhibitors after liver transplantation
(Itxarone Bilbao, Gonzalo Sapisochin.Cristina Dopazo,Jose Luis Lazaro, Leonor Pou, Luis Castells. Mireia Caralt,Amaia Gantxegi,Ramon Charco)

*Evolution of Immunosuppression in Liver Transplantation
(Olga N. Tucker, Nigel Heaton, The Liver Transplant Unit, Institute of Liver Studies, King's College Hospital, London, UK)

*The Role of Pharmacogenomics in Tailoring Immunosuppressive Therapy for Liver Transplant Recipients
(Nyingi Kemmer, Univ. of Cincinnati, Cincinnati VA Medical Center, Pankaj B. Desai, Univ. of Cincinnati, Guy W. Neff, Univ. of Cincinnati)

Immunosuppression caused by photochemo-and photodynamic therapy: focus on photosensitizer photoproducts
(Kyagova A.A, Malakhov M.V, Potapenko A. Ya., Russian State Medical University,Moscow)

Sunlight Induced Immunosuppression: A Role for Inflammatory Mediators in the Induction of Suppressor Cells
(Scott N. Byrne and Gary M. Halliday, Dermatology Research Laboratories, University of Sydney, Australia)

Immunosuppressive therapy in adult to adult living- related liver transplantation
(S. Gruttadaurial,J Vigano,J.W Marsh,A.Marcos,B. Gridelli)

High-dose Immunosuppression with Autologous Stem Cell Transplantation in Severe Refractory Systemic Lupus Erythematosus;
(Igor A. Lisukov, Novosibirsk State Medical Univ., Vera V. Sergeevicheva, Svetlana A. Sizikova, Institute of Clinical Immunology, Novosibirsk, Russia,)

Experimental Approaches for Transplantation of Islets in the Absence of Immunosuppression;
(Bart J de Haan and Marijke M. Faas et al., University of Groningen, The Netherlands)

Oxidative Stress Peripheral Markers in Graves' Disease Ophthalmopathy Patients During Combined Immunosuppression
(Janusz Bednarek et al., Poznań University of Medical Sciences, Poland)


   Binding: ebook
   Pub. Date: 2009 3rd Quarter
   Pages: 304 pp.
   ISBN: 978-1-60876-707-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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