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Molecular Therapy of Breast Cancer: Classicism Meets Modernity
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Authors: Marc Lacroix (InTextoResearch, Baelen, Belgium and Université Libre de Bruxelles, Brussels, Belgium) 
Book Description:
Breast cancer is the most frequently diagnosed type of cancer and a second leading cause of cancer death in women after lung cancer. Despite their proven efficacy, classical therapies are, however, unable to cure metastatic breast cancer and are often associated with significant toxicity and side-effects, due to a wide spectrum of action. During the last years, our increasing knowledge of the molecular pathways underlying cancer development has led to the introduction of new drugs, of which most are directed towards very specific targets. Rather than to be used as single agents, these “modern” compounds could ultimately be combined with classical molecules.
Here are described nearly 150 drugs that are currently used in routine therapy or are in clinical trials in breast cancer patients. From the classical tamoxifen, fluorouracil, cyclophosphamide, doxorubicin, epirubin, docetaxel, paclitaxel…, to the more recently introduced ixabepilone, lapatinib, vorinostat, everolimus, bevacizumab…, they also include capecitabine, gemcitabine, trastuzumab, bevacizumab, fulvestrant, aromatase inhibitors, cancer vaccines, inhibitors of tumor-induced osteolysis, insulin-like growth factor-I receptor inhibitors, poly(ADP-ribose) polymerase (PARP)-1 inhibitors, and many others.
This book offers an insight into current developments of breast cancer therapy, when classicism meets modernity.

Table of Contents:
Chapter 1. Introduction pp.1-4

Chapter 2. Selective estrogen receptor modulators (SERMs) and down-regulators pp.5-18 (SERDs)

Chapter 3. Aromatase inhibitors pp.19-32

Chapter 4. Agents inducing ovarian suppression pp.33-40

Chapter 5. Antimetabolites pp.41-56

Chapter 6. Alkylating agents pp.57-76

Chapter 7. Anthracyclines pp.77-88

Chapter 8. Microtubule-binding agents pp.89-116

Chapter 9. Topoisomerase inhibitors pp.117-122

Chapter 10. HER family inhibitors pp.123-144

Chapter 11. Angiogenesis inhibitors pp.145-156

Chapter 12. Insulin-like growth factor-I receptor inhibitors pp.157-164

Chapter 13. RAS-RAF-MEK-ERK pathway inhibitors pp.165-172

Chapter 14. Ubiquitin-proteasome system inhibitors pp.173-176

Chapter 15. Histone deacetylases inhibitors pp.177-184

Chapter 16. Mitotic inhibitors pp.185-190

Chapter 17. Inhibitors of heat-shock proteins 90 and 27 pp.191-196

Chapter 18. PI3K/AKT/mTOR pathway inhibitors pp.197-206

Chapter 19. Cyclooxygenase-2 inhibitors pp.207-212

Chapter 20. Poly(ADP-ribose) polymerase (PARP)-1 inhibitors pp.213-218

Chapter 21. Tumor-induced osteolysis inhibitors pp.219-232

Chapter 22. Vaccines and immunomodulators pp.233-256

Chapter 23. Varia pp.257-274

Index pp.275-291

   Series:
      Cancer Etiology, Diagnosis and Treatments
   Binding: Hardcover
   Pub. Date: 2009 3rd quarter
   ISBN: 978-1-60741-593-0
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Molecular Therapy of Breast Cancer: Classicism Meets Modernity