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Multiple Sclerosis: A New Paradigm
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Editors: Michel Geffard (University of Bordeaux, Pessac, France)
Book Description:
Multiple Sclerosis (MS) is an inflammatory, autoimmune and degenerative disease of the central nervous system (CNS). Depending on the region affected, MS is a CNS disease of complex evolution n, and is individual for each patient. However, clinically it has been recognised that in 85% of patients, the disease starts with a relapsing-remitting form. In a genetically predisposed patient, certain components of Gram-negative bacteria living in the mucous biotope would lie at the origin of immune system reactivation and the autoimmune components involved in the destruction of the actual tissues targeted. Thus, a new paradigm can be proposed; the Gram-negative bacteria that live in the intestinal epithelium and on other mucosal barriers, frequently rendered fragile by different external agents, would stimulate the immune system. This book presents and discusses research in the study of this new paradigm. (Imprint: Nova Biomedical Press)

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Table of Contents:
Chapter 1. A Historic Perspective on Multiple Sclerosis
(Dolores González-Morón and Pablo Villoslada) pp.1-20

Chapter 2. Bacterial Role in the Development of Chronic Multiple Sclerosis
(Alan Ebringer and Taha Rashid)pp.21-36

Chapter 3. Animal Models of Multiple Sclerosis
(Beatriz Moreno and Pablo Villoslada)pp.37-68

Chapter 4. Immunopathology and Immuumunomodulation in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
(R. Coveñas, A. Mangas, S. Duleu, F. de Castro, M. Merchán and M. Geffard)pp.69-132

Chapter 5. Indirect Visualization of Specified Antigenic modifications induced by nitric oxide in an experimental Model of allergic encephalomyelitis
(D. Bodet, A. Mangas, R. Coveñas, M.P. Dabadie and M. Geffard)pp.133-152

Chapter 6. A New Paradigm for Multiple Sclerosis
(Michel Geffard, Sébastien Duleu, Alban Bessede, Rafael Covenas, Arturo Mangas) pp.153-184

Index pp.185-199

      Neurodegenerative Diseases - Laboratory and Clinical Research
   Binding: Hardcover
   Pub. Date: 2011
   Pages: 199.pp
   ISBN: 978-1-61122-642-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Multiple Sclerosis: A New Paradigm