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Unraveling the Genetics of Bovine Johne's Disease
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Authors: Chris P. Verschoor, Sameer D. Pant, Niel A. Karrow (University of Guelph, Guelph, ON) 
Book Description:
Johne’s disease is a chronic, granulomatous enteritis of ruminants and some wild-type species that is caused by infection with Mycobacterium avium spp. paratuberculosis (MAP). This inflammatory bowel disease (IBD) is characterized by a lengthy yet variable asymptomatic subclinical phase in which infected animals can transmit MAP to their progeny and herd mates; this is followed by a clinical phase characterized by chronic diarrhea, wasting, and eventually death. The impact of Johne’s disease is particularly evident in the dairy and beef industries, where significant losses due to reduced productivity and fertility, mortality, and premature culling have been reported. This book addresses the genetics of this condition and its possible treatments.



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Table of Contents:
Introduction, pp. 1-3

1. MAP and the Bovine Immune Response, pp. 5-6

2. A Role for CD8+ and ãä-T Cells in Early Infection, pp. 7-8

3. The Host Response during the sub-clinical phase of infection, pp. 9-12

4. Clinical phase, pp. 13-14

5. Pathological similarities between Johne’s disease and Crohn’s disease, pp. 15-20

6. A genetic basis for mammalian IBDs, pp. 21-24

7. Potential susceptibility loci conserved across mammalian IBDs, pp. 25-30

8. Impact of alternate mechanisms of gene regulation, pp. 31-34

9. Conclusion, pp. 35-63

Index

   Series:
      Digestive Diseases - Research and Clinical Developments
   Binding: Softcover
   Pub. Date: 2011
   Pages: 6 x 9
   ISBN: 978-1-61668-204-0
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Unraveling the Genetics of Bovine Johne's Disease