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Small Stress Proteins and Human Diseases
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Authors: Stéphanie Simon and André-Patrick Arrigo (Claude Bernard University, Villeurbanne, France) 
Book Description:
Essential for the defense against all kinds of stress, small stress proteins also play major roles in the physiology, development and differentiation of human cells. In spite of their beneficial roles, small stress proteins can also be deleterious for the organism, notably in some cancer pathologies where they can, through their anti-apoptotic properties, favor tumor development and interfere with the cytotoxic activity of anti-cancer drugs. This book proposes a focus on the recent knowledge in the field of the expression and putative role of small stress proteins in human health and diseases.

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Table of Contents:
PREFACE

INTRODUCTION TO SMALL HEAT SHOCK PROTEINS;pp. 1-27
(Chantel van de Schootbrugge, Wilbert C. Boelens, Radboud Univesity, Nijmegen, The Netherlands)

PART 1: PROTECTIVE FUNCTIONS OF SMALL HEAT SHOCK PROTEINS, ROLES IN CONFORMATIONAL, INFLAMMATION AND REDOX STATE RELATED DISEASES.

CHAPTER 1.1: CYTOPROTECTIVE FUNCTION OF SMALL STRESS PROTEINS TO FIGHT PROTEIN CONFORMATIONAL DISEASES.;pp. 31-53
(Serena Carra and Harm H. Kampinga,University of Groningen, Groningen, The Netherlands)

CHAPTER 1.2: FUNCTIONAL SYMBIOSIS BETWEEN THE INTERMEDIATE FILAMENT CYTOSKELETON AND SMALL HEAT SHOCK PROTEINS;pp. 55-87
(Andrew Landsbury, Ming Der Perng, Ehmke Pohl , Roy A. Quinlan, Durham University, UK and others)

CHAPTER 1.3: THE TWO LENS STRUCTURE PROTEINS, aA-CRYSTALLIN (HSPB4) AND aB-CRYSTALLIN (HSPB5), CONTROL APOPTOSIS THROUGH REGULATION OF MULTIPLE SIGNALING TRANSDUCTION PATHWAYS.;pp. 89-116
(David W. Li*, Lili Gong, Mi Deng, Jinping Liu, Mugen Liu, and Ying-Wei Mao, University of Nebraska Medical Center, Omaha and others)

CHAPTER 1.4: SMALL STRESS PROTEINS IN THE CENTRAL NERVOUS SYSTEM: FROM NEURODEGENERATION TO NEUROPROTECTION;pp. 117-146
(Andreas Wyttenbach*, Sarah Hands and Vincent O’Connor, University of Southhampton, UK)

CHAPTER 1.5: SMALL STRESS PROTEINS IN PROTECTING THE HEART;pp. 147-169
(Guo-Chang Fan* and Evangelia G. Kranias, University of Cincinnati College of Medicine, OH)

CHAPTER 1.6: PROTEIN QUALITY CONTROL IN HEART DISEASE: SMALL HEAT SHOCK PROTEINS AND AUTOPHAGY;pp. 171-188
(Paul Tannous, Beverly A. Rothermel and Joseph A. Hill, University of Texas Southwestern Medical Center, Dallas)

CHAPTER 1.7: THE TWO-FACED NATURE OF SMALL HEAT-SHOCK PROTEINS: AMYLOID FIBRIL ASSEMBLY AND THE INHIBITION OF FIBRIL FORMATION; REVELEVANCE TO DISEASE STATES;pp. 189-211
(Heath Ecroyd, Sarah Meehan and John A. Carver, University of Wollongong, Australia and others)

PART II : MUTATIONS IN SMALL STRESS PROTEINS RESPONSIVE OF HUMAN DISEASES

CHAPTER 2.1: FROM SEQUENCE TO PATHOLOGY: THE REQUIRED INTEGRITY OF THE STRUCTURE-DYNAMICS-FUNCTION RELATIONSHIPS AT THE MOLECULAR LEVEL;pp. 215-244
(Annette Tardieu, Magalie Michiel, Fériel Skouri-Panet, Elodie Duprat, Stéphanie Simon, Stéphanie Finet, Institut de Mineralogie et de Physique des Milieux Condenses, Paris, France and others)

CHAPTER 2.2: ALPHA-CRYSTALLINS (HSPB4 AND HSPB5) AND CATARACT DISEASES;pp. 245-262
(Ushua Andley, Washington University
School of Medicine, St. Louis, Missouri,USA)

CHAPTER 2.3: aB-CRYSTALLIN (HSPB5) AND MYOFIBRILLAR MYOPATHIES.;pp. 263-285
(Isidre Ferrer*, Dolores Moreno, Anna Janué, Idibell-Hospital Universitari de Bellvitge, Universitat de Barcelona, Ciberned,Spain)

CHAPTER 2.4: HSPB5 (CRYAB; aB-CRYSTALLIN), PROTEIN AGGREGATION AND CARDIOMYOPATHY;pp. 287-300
(University of Utah School of Medicine, Salt Lake City, USA)

CHAPTER 2.5: HSPB1 AND HSPB8 MUTATIONS IN NEUROPATHIES;pp. 301-324
(Rainer Benndorf; The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus,USA)
Introduction

PART III : SMALL HEAT SHOCK PROTEINS IN CANCER DISEASES

CHAPTER 3.1: SMALL STRESS PROTEINS, BIOMARKERS OF CANCER;pp. 327-351
(Daniel R. Ciocca, Mariel A. Fanelli, F. Dario Cuello-Carrion, Gisela N. Castro, National Research Council, Argentine Foundation for Cancer Research, Casilla de Correo, Mendoza, Argentina

CHAPTER 3.2: SMALL HEAT SHOCK PROTEINS AS POTENTIAL MESSENGERS IN THE PATHWAYS TO CANCER;pp. 353-377
(Anastassiia Vertii and Matthias Gaestel,University of Massachusetts Medical School, Worcester, Ma. USA and others)

CHAPTER 3.3: HSP16.2 IN BRAIN CANCERs;pp. 379-385
(Szabolcs Bellyei*, Eva Pozsgai, Balazs Sumegi, Univer5sity of Pecs, Dept. of Oncotherapy, Dept. of Biochemistry and Medical Chemistry, Pecs))

CHAPTER 3.4: SMALL HEAT SHOCK PROTEIN HSP27 (HSPB1), aB-CRYSTALLIN (HSPB5) AND HSP22 (HSPB8): APOPTOTIC AND TUMORIGENIC FUNCTIONS;pp. 387-414
(Aurelie de Thonel, Guillaume Wettstein, Anne-Laure Joly, Nathalie Decologne, Adonis Hazoumé, Carmen Garrido,Inserm U-866, Faculty of Medicine and Pharmacy, Dijon, France and others)

PART IV : THERAPEUTIC APPROACHES

CHAPTER 4.1: SMALL STRESS PROTEINS AND THEIR THERAPEUTIC POTENTIAL;pp. 417-438
(Scott Houck, Joy G. Ghosh, John I Clark, University of Washington,Seattle,USA and others)

CHAPTER 4.2: ANTISENSE AND RNAI APPROACHES TO INTERFERE WITH HSP27 (HSPB1) ACTIVITY IN CANCER;pp. 439-455
(Amina Zoubeidi and Martin E Gleave, The Vancouver Prostate Centre and Dept. of Urological Sciences, University of British Columbia, Canada)

CHAPTER 4.3: BENEFICIAL AND DELETERIOUS, THE DUAL ROLE OF SMALL STRESS PROTEINS IN HUMAN DISEASES: IMPLICATIONS FOR THERAPEUTIC STRATEGIES;pp. 457-476
(Stephanie Simon, Andre-Patrick Arrigo, Claude Bernard University Lyon, Villeurbanne Cedex, France)

LIST OF THE CORRESPONDING AUTHORS

INDEX

   Series:
      Protein Science and Engineering
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 7 x 10, 492 pp
   ISBN: 978-1-61668-198-2
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Small Stress Proteins and Human Diseases