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Biomaterials in Blood-Contacting Devices: Complications and Solutions
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Authors: Meng-Jiy Wang (Department of Chemical Engineering, National Taiwan University of Science and Technology) and Wei-Bor Tsai (Department of Chemical Engineering, National Taiwan University) 
Book Description:
All blood-contacting medical devices in use today are subjected to some degree poorer blood compatibility than the native artery. Hemostatic mechanism, arresting bleeding from injured blood vessels, induces platelet adhesion and activation onto artificial biomaterials, which leads to undesirable outcomes such as blood clotting at the site of the implant, continual shedding of thrombi, and depletion of platelets from the blood stream. Such complications have hampered the clinical success of blood contacting devices, limiting the patent of small-diameter vascular grafts and making necessary the use of anticoagulants in patients undergoing extracorporeal bypass or synthetic heart valve implantation. Therefore, development of non-thrombogenic biomaterials is in great need for blood contacting devices. The current approaches mainly focus on surface modifications with biological anticoagulants such as heparin, or anti-fouling molecules like poly(ethylene oxide). In this review, the authors first introduce the blood components involved in hemostasis and thrombosis, followed by the common biomaterials applied in blood-contacting devices. Next, the complications induced by the interactions between blood and biomaterials are briefly addressed. Finally, the commonly used techniques for improving biomaterials’ hemocompatibility are expatiated.



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Table of Contents:
Abstract

Chapter 1. Introduction, pp. 1-2

Chapter 2. Blood Components Involved in Hemostasis and Thrombosis, pp. 3-12

Chapter 3. Blood-contacting Devices and Materials, pp. 13-20

Chapter 4. Blood-Materials Interactions, pp. 21-25

Chapter 5. Surface Modification for Improving Blood Compatibility, pp. 27-43

Chapter 6. Conclusion, pp. 45

References
Index

   Series:
      Biomaterials - Properties, Production and Devices
   Binding: Softcover
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-60876-784-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Biomaterials in Blood-Contacting Devices: Complications and Solutions